{"id":"W4220700535","doi":"10.1158/1538-7445.sabcs21-ot1-12-04","title":"Abstract OT1-12-04: A phase 3, open-label trial of neoadjuvant trastuzumab deruxtecan (T-DXd) monotherapy or T-DXd followed by THP compared with ddAC-THP in patients with high-risk HER2-positive early-stage breast cancer (DESTINY-Breast11)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Trastuzumab; Internal medicine; Oncology; Pertuzumab; Breast cancer; Gastroenterology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001275532,0.001722454,0.001767918,0.000400773,0.0004703148,0.001322177,0.000921072,0.001405612,0.005289273],"category_scores_gemma":[0.0007998107,0.0004989566,0.001347792,0.0004184836,0.001263406,0.001031672,0.0003259348,0.004216309,0.001094985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031819,"about_ca_system_score_gemma":0.001525827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001388734,"about_ca_topic_score_gemma":0.004333144,"domain_scores_codex":[0.9996973,0.0001439099,0.00001302324,0.00004884212,0.00002347785,0.0000735368],"domain_scores_gemma":[0.9993718,0.0001230121,0.0001155816,0.00004561585,0.00003447529,0.0003095471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.878275,0.04981418,0.001778279,0.0005961562,0.0006178277,0.0001354192,0.0001894728,0.001232213,0.0200714,0.0003023122,0.00366644,0.04332134],"study_design_scores_gemma":[0.7156894,0.2766552,0.003309855,0.00003298394,0.0002142947,0.0001193271,0.00005133815,0.0009619649,0.00155956,0.0001887094,0.001191117,0.00002622519],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911646,0.001400672,0.000418006,0.0006420228,0.0002370276,0.002289867,0.001524322,0.0001551382,0.002168325],"genre_scores_gemma":[0.9832222,0.001616744,0.001879426,0.001481415,0.0002510786,0.003198222,0.002989054,0.00005510197,0.005306756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005289273,"threshold_uncertainty_score":0.01769441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03987498572126909,"score_gpt":0.3681491491813673,"score_spread":0.3282741634600982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}