{"id":"W4220701929","doi":"10.3389/fnmol.2022.852181","title":"Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Axotomy; TRPV1; Capsazepine; Reactive oxygen species; Axon; Chemistry; Cell biology; Transient receptor potential channel; Calcium; Nerve injury; Voltage-dependent calcium channel; Neuroscience; Biology; Receptor; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820423,0.0001821858,0.0002549935,0.000273378,0.0003536108,0.00004554673,0.0003876821,0.00005034664,0.00001510301],"category_scores_gemma":[0.0004268806,0.0001857375,0.00009075941,0.000703496,0.0003326096,0.0002838658,0.0002777923,0.0003444928,3.224526e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001176284,"about_ca_system_score_gemma":0.00008163267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001821344,"about_ca_topic_score_gemma":3.191874e-7,"domain_scores_codex":[0.9975454,0.000375623,0.0002804021,0.0006736746,0.0007435148,0.0003814358],"domain_scores_gemma":[0.9994867,0.00005957864,0.0001652794,0.0001799104,0.00001464927,0.00009381612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007133737,0.000066958,0.0004921944,0.000007159285,0.000001609622,0.00009539622,0.0007793863,0.001492734,0.9963177,0.0001014048,0.0003276512,0.0002464748],"study_design_scores_gemma":[0.0007091307,0.0001560964,0.0008115044,0.00001111542,0.000007589247,0.00001978906,0.0009827905,0.006854448,0.9838074,0.0002160819,0.006187352,0.0002366452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780989,0.00006344534,0.01380897,0.0002814654,0.00674884,0.0004223549,0.00003091296,0.00003368779,0.000511416],"genre_scores_gemma":[0.9978417,0.00003416616,0.0008771729,0.0006285697,0.00006292994,0.00004234049,0.000004841253,0.00002227454,0.0004860453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01974275,"threshold_uncertainty_score":0.7574157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032790220481524,"score_gpt":0.2452169260774675,"score_spread":0.2248890238726523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}