{"id":"W4220703997","doi":"10.1158/1541-7786.mcr-21-0780","title":"Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers","year":2022,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; University of British Columbia","funders":"European Commission; National Institute for Health and Care Research; Cancer Research UK; Prostate Cancer UK; Movember Foundation","keywords":"Prostate; Prostate cancer; Signal transduction; Cancer; Interleukin 8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001535815,0.0002469485,0.0004615287,0.0006078753,0.0006941776,0.0000877749,0.000206263,0.00005248843,0.0002658788],"category_scores_gemma":[0.0001150945,0.0002253609,0.00007896811,0.00130762,0.0003807368,0.0001083696,0.0002634095,0.001402944,0.000007029248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002825169,"about_ca_system_score_gemma":0.00187745,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01745377,"about_ca_topic_score_gemma":0.000491331,"domain_scores_codex":[0.9955533,0.0007067083,0.0003486811,0.0007611633,0.001476023,0.00115409],"domain_scores_gemma":[0.9987439,0.0001725499,0.00008098603,0.0003498558,0.0003476573,0.0003050884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01491349,0.0002959907,0.1586087,0.0003875582,0.0004703822,0.01099208,0.00347544,0.003167896,0.8011338,0.0001767253,0.00137031,0.005007599],"study_design_scores_gemma":[0.08749565,0.01853062,0.050416,0.003471931,0.0005183669,0.0006633981,0.03533683,0.05032458,0.7219075,0.001571815,0.02691137,0.002851905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809216,0.01262062,0.0000166393,0.003138493,0.00006288097,0.002162175,0.0001598001,0.00004791607,0.0008698985],"genre_scores_gemma":[0.9949419,0.0005337496,0.00009555391,0.000380857,0.00006457559,0.002528546,0.00005130145,0.00007542468,0.001328129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1081927,"threshold_uncertainty_score":0.9890891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04664584518569838,"score_gpt":0.364057248176534,"score_spread":0.3174114029908356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}