{"id":"W4220705962","doi":"10.1186/s12885-022-09283-z","title":"PSMA PET/CT guided intensification of therapy in patients at risk of advanced prostate cancer (PATRON): a pragmatic phase III randomized controlled trial","year":2022,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Institute of Health Economics; University of Alberta; BC Cancer Agency; University of Calgary; Princess Margaret Cancer Centre; Western University; University of Toronto; McMaster University; London Health Sciences Centre; University of British Columbia; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Cancer Society; Lantheus Medical Imaging","keywords":"Medicine; Prostate cancer; Prostatectomy; Randomized controlled trial; Clinical endpoint; Radiation therapy; Quality of life (healthcare); Positron emission tomography; Surgical oncology; Prostate; Adverse effect; Oncology; Cancer; Internal medicine; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008711306,0.0002540558,0.002117396,0.0001923048,0.00007815257,0.000004991414,0.00009763992,0.00001238992,0.0008072548],"category_scores_gemma":[0.0003399084,0.0001823503,0.0004555273,0.0003094652,0.0001111662,0.00006558796,0.00005550062,0.0001505725,9.373796e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001062987,"about_ca_system_score_gemma":0.0006117575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002381938,"about_ca_topic_score_gemma":0.0003763311,"domain_scores_codex":[0.9968663,0.00053264,0.001413068,0.0003774783,0.0005447262,0.0002657585],"domain_scores_gemma":[0.9972059,0.0003993192,0.001569125,0.0003761481,0.0003697122,0.00007978769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9339879,0.002405346,0.05071908,0.0001166238,0.0007032962,0.000008696658,0.0009641435,0.001337828,0.0005890582,0.000012208,0.0004701682,0.008685716],"study_design_scores_gemma":[0.986221,0.002064215,0.005591318,0.0002198121,0.0006685285,0.000002471874,0.0001928663,0.001104247,0.00325748,0.00004330622,0.0004793934,0.0001553942],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736505,0.006763063,0.000007406118,0.0002647027,0.0005851206,0.01815716,0.0004743386,0.0000197632,0.00007800933],"genre_scores_gemma":[0.9595689,0.008327898,0.0001411732,0.0001299401,0.00004336164,0.03118892,0.0001607993,0.00003513969,0.0004038411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05223313,"threshold_uncertainty_score":0.8838874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780347680359867,"score_gpt":0.323054044164832,"score_spread":0.3052505673612333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}