{"id":"W4220708647","doi":"10.1016/j.clon.2022.03.006","title":"Liver Immune-related Adverse Effects of Programmed Cell Death 1 (PD-1) and Programmed Cell Death Ligand 1 (PD-L1) Inhibitors: A Propensity Score Matched Study with Competing Risk Analyses","year":2022,"lang":"en","type":"letter","venue":"Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Programmed cell death 1; Medicine; PD-L1; Programmed cell death; Propensity score matching; Adverse effect; Immune system; Oncology; Apoptosis; Internal medicine; Immunology; Immunotherapy; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004253377,0.0002170996,0.0008307121,0.0003908227,0.0005100294,0.00095269,0.0003712281,0.001987736,0.00189407],"category_scores_gemma":[0.0178179,0.00027716,0.0007761063,0.001015954,0.0003878089,0.0005575402,0.0002939398,0.001624048,0.0004175681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006712724,"about_ca_system_score_gemma":0.0006584405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001533581,"about_ca_topic_score_gemma":0.003197019,"domain_scores_codex":[0.9968736,0.00197293,0.0003055219,0.0002554077,0.0003839968,0.0002086415],"domain_scores_gemma":[0.9869675,0.008256261,0.001968541,0.001197994,0.001039887,0.0005699072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01494635,0.0003526643,0.8062519,0.0002598498,0.001983091,0.01107462,0.0002440195,0.0008192089,0.001063536,0.003502888,0.09075557,0.0687463],"study_design_scores_gemma":[0.008006778,0.003721071,0.7601073,0.0004644845,0.004498533,0.06326943,0.001450514,0.03298895,0.002701078,0.0315874,0.09086678,0.0003376169],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8108997,0.006597784,0.00433229,0.1593435,0.005041655,0.0001520164,0.002727728,0.00007739126,0.01082781],"genre_scores_gemma":[0.9466152,0.001310785,0.001656674,0.03834043,0.007633801,0.00009464552,0.0006547541,0.00002208969,0.003671617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004253377,"threshold_uncertainty_score":0.02249426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07959562166458727,"score_gpt":0.3647466321096888,"score_spread":0.2851510104451015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}