{"id":"W4220709661","doi":"10.1096/fj.202101552rr","title":"Fetal glucocorticoid exposure leads to sex‐specific changes in drug‐transporter function at the blood‐brain barrier in juvenile guinea pigs","year":2022,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Offspring; Betamethasone; Sexual dimorphism; Fetus; Glucocorticoid; Pregnancy; Drug; Juvenile","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001471578,0.0002632142,0.0003158925,0.0003098374,0.0001621246,0.0002930746,0.000237233,0.0003734491,0.001543964],"category_scores_gemma":[0.0001880694,0.0002840285,0.0003601968,0.00008693461,0.0004787059,0.00022368,0.0002120159,0.001174596,0.0003159898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003184139,"about_ca_system_score_gemma":0.000211612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001890919,"about_ca_topic_score_gemma":0.003195832,"domain_scores_codex":[0.9998052,0.00002535119,0.00001224729,0.00006271913,0.00003474925,0.00005975593],"domain_scores_gemma":[0.9997101,0.00004946366,0.00008710715,0.00003367619,0.00001985136,0.00009963368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008928014,0.0001729577,0.001604452,0.00003192402,0.00001064263,0.0003841309,0.0001041688,0.00002575622,0.994447,0.00005779524,0.00008865051,0.00217969],"study_design_scores_gemma":[0.0001974035,0.01473722,0.2006708,0.0000616979,0.0001631254,0.002002402,0.0009281559,0.0007065656,0.7754358,0.00019991,0.00483248,0.00006447609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982359,0.0005644894,0.0003242715,0.0001225274,0.00003310854,0.00001482883,0.000234408,0.0000223315,0.0004479849],"genre_scores_gemma":[0.9935722,0.0009058244,0.0005349851,0.0002038672,0.00001759111,0.00007072504,0.0003523137,0.00002303365,0.004319322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001890919,"threshold_uncertainty_score":0.0051651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148141669173616,"score_gpt":0.2185032282277881,"score_spread":0.2070218115360519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}