{"id":"W4220713221","doi":"10.1158/1538-7445.sabcs21-p1-18-05","title":"Abstract P1-18-05: Early changes in circulating tumor DNA and its effect on clinical outcomes in patients with advanced breast cancer receiving the CDK4/6 inhibitor palbociclib: Genotyping results from POLARIS","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Palbociclib; Medicine; Oncology; Internal medicine; Breast cancer; Cancer; Genotyping; Metastatic breast cancer; Genotype; Gene; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007371507,0.0003532643,0.0003464621,0.000644002,0.000314254,0.0007384088,0.0004173114,0.0003135618,0.00268081],"category_scores_gemma":[0.001699416,0.0002011109,0.0002232684,0.00105424,0.00031358,0.0002457572,0.0004210996,0.0005113734,0.0007855297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009279833,"about_ca_system_score_gemma":0.0007549525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0121082,"about_ca_topic_score_gemma":0.01473718,"domain_scores_codex":[0.9995296,0.0001130711,0.00003262106,0.0001511548,0.0001244581,0.00004899617],"domain_scores_gemma":[0.9984038,0.0002676084,0.0006235954,0.00008117768,0.0003842024,0.0002396652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003354032,0.00006011242,0.9885464,0.00003193728,0.00007134586,0.00006060967,0.00003798297,0.00009572697,0.001074345,0.00001997626,0.001349983,0.005297507],"study_design_scores_gemma":[0.0004525904,0.0006826844,0.9940208,0.00001990663,0.00009157198,0.0003485072,0.0001124657,0.0003647774,0.001228069,0.00003680729,0.002635154,0.000006675737],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875946,0.000739922,0.0001948404,0.0002456256,0.00002895818,0.00004904184,0.00910611,0.00002442384,0.002016462],"genre_scores_gemma":[0.9891196,0.0002564898,0.0002719777,0.0001460215,0.00003952083,0.00004257551,0.009085773,0.00001084823,0.001027138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0121082,"threshold_uncertainty_score":0.02407545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06046124020476749,"score_gpt":0.3998349772114765,"score_spread":0.339373737006709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}