{"id":"W4220714022","doi":"10.1158/1538-7445.sabcs21-p5-17-05","title":"Abstract P5-17-05: A phase I/Ib study of inavolisib (GDC-0077) in combination with fulvestrant in patients (pts) with <i>PIK3CA</i>-mutated hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Fulvestrant; Medicine; Metastatic breast cancer; Internal medicine; Breast cancer; Oncology; Cancer; Combination therapy; Phases of clinical research; Chemotherapy; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001136222,0.0004541416,0.0009492435,0.001004997,0.0002480753,0.00003679157,0.0003880574,0.00006600882,0.0009611892],"category_scores_gemma":[0.00005362097,0.0003757593,0.00005703008,0.003552445,0.0005287334,0.0004541193,0.0001634622,0.001658751,0.000003157633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003199042,"about_ca_system_score_gemma":0.001326266,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02728062,"about_ca_topic_score_gemma":0.008312696,"domain_scores_codex":[0.9941124,0.0007491037,0.0007684721,0.0009339733,0.002462254,0.000973835],"domain_scores_gemma":[0.9972701,0.0003157176,0.0003778552,0.0005386962,0.001233173,0.0002644472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2849368,0.07907245,0.3777099,0.001018544,0.002631667,0.001729895,0.07713936,0.02125004,0.03408946,0.00006655589,0.001378717,0.1189767],"study_design_scores_gemma":[0.1143813,0.02213506,0.8305598,0.001304154,0.0001475118,0.00004497097,0.0253932,0.0002056867,0.004892346,0.00007898236,0.0002144357,0.0006425073],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926511,0.0006032583,0.00001941563,0.0008149786,0.00007174717,0.004799766,0.0008469396,0.00004288695,0.0001499282],"genre_scores_gemma":[0.995659,0.0001476606,0.0001411455,0.00009726762,0.00004412401,0.003469178,0.0001634319,0.0001235172,0.0001546589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.45285,"threshold_uncertainty_score":0.9999521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03702796251358815,"score_gpt":0.3804772975894919,"score_spread":0.3434493350759038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}