{"id":"W4220718803","doi":"10.1038/s41380-022-01441-w","title":"Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills","year":2022,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Environmental Health Sciences; Helse Sør-Øst RHF; Instituto de Salud Carlos III; National Institutes of Health; Economic and Social Research Council; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Institut pour la Recherche en Santé Publique; Novo Nordisk Fonden; Mutuelle Générale de l'Education Nationale; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; National Institute on Drug Abuse; Novo Nordisk; Juho Vainion Säätiö; Canadian Institutes of Health Research; Yrjö Jahnssonin Säätiö; Jane ja Aatos Erkon Säätiö; National Institute of Mental Health; Fondation pour la Recherche Médicale; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Päivikki ja Sakari Sohlbergin Säätiö; Suomen Lääketieteen Säätiö; Academy of Finland; Erasmus Universiteit Rotterdam; Eunice Kennedy Shriver National Institute of Child Health and Human Development; ZonMw; Institut National de la Santé et de la Recherche Médicale; Norges Forskningsråd; Erasmus Medisch Centrum; Centres de Recerca de Catalunya; University of Bristol; Deutsche Forschungsgemeinschaft; Helsingin Yliopisto; European Commission; Jalmari ja Rauha Ahokkaan Säätiö; Joint Programming Initiative A healthy diet for a healthy life; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; CHIST-ERA; Agence Nationale de la Recherche; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Fundació la Marató de TV3; Université Paris-Sud; Emil Aaltosen Säätiö; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Epigenetics; Epigenome; DNA methylation; Cognition; CpG site; Cord blood; Psychology; Population; Genetics; Developmental psychology; Biology; Medicine; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001606017,0.0005930312,0.003176098,0.0005123486,0.0004046414,0.00002675423,0.0003518557,0.0002441084,0.006848748],"category_scores_gemma":[0.0002390398,0.0005706939,0.002287786,0.001909973,0.0001764705,0.0001151092,0.0006360092,0.0005897837,0.0001534972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006089971,"about_ca_system_score_gemma":0.0001000792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001202635,"about_ca_topic_score_gemma":0.000121534,"domain_scores_codex":[0.9944004,0.001661655,0.001209253,0.001305855,0.0009329054,0.000489947],"domain_scores_gemma":[0.9965654,0.001011941,0.00152437,0.000655141,0.00001060747,0.0002325374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000005216711,0.001193006,0.1271691,0.001872587,0.499979,0.00003194025,0.001616287,0.0002921378,0.00001019495,0.0000922297,0.0002195061,0.3675188],"study_design_scores_gemma":[0.0003055707,0.0001004047,0.1378916,0.0001072846,0.6689854,0.000002122714,0.00007162021,0.00000317227,0.00001419926,0.0004129116,0.191129,0.0009767122],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005626041,0.9858736,0.001322413,0.0001460846,0.00009668925,0.001730668,0.002982857,0.00003639104,0.002185268],"genre_scores_gemma":[0.004992151,0.9897027,0.0008883334,0.0006520211,0.0000381788,0.0003464717,0.002955667,0.0001372332,0.0002872533],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3665421,"threshold_uncertainty_score":0.9996744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04866048219032457,"score_gpt":0.3169915113610341,"score_spread":0.2683310291707095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}