{"id":"W4220719444","doi":"10.1158/1538-7445.sabcs21-pd2-05","title":"Abstract PD2-05: Genomic profiling of PAM50-based intrinsic subtypes in HR+/HER2- advanced breast cancer (ABC) across the MONALEESA (ML) studies","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Indel; Medicine; Oncology; False discovery rate; Exact test; Internal medicine; Breast cancer; Logistic regression; Multiple comparisons problem; Gene; Cancer; Bioinformatics; Biology; Genetics; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001883126,0.0003166974,0.000697537,0.0003162391,0.0006050097,0.00002551111,0.0006301856,0.00007506697,0.0008368205],"category_scores_gemma":[0.0001489049,0.0002454359,0.0001513999,0.001490512,0.00100097,0.0001591101,0.000482555,0.00160839,0.000008357244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002716425,"about_ca_system_score_gemma":0.001714761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00230842,"about_ca_topic_score_gemma":0.001635736,"domain_scores_codex":[0.9958366,0.0003061307,0.0006225629,0.0007244921,0.001383389,0.001126839],"domain_scores_gemma":[0.9974649,0.0005979681,0.0002367719,0.0007711229,0.0007773809,0.000151887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01864686,0.0007125485,0.1522598,0.001925539,0.0008204213,0.0002669705,0.008952126,0.04769132,0.465463,0.0002364163,0.0005398096,0.3024851],"study_design_scores_gemma":[0.01187683,0.0008061588,0.7959216,0.001481468,0.00009107736,0.0001110495,0.03592975,0.0003401757,0.1318177,0.0009759137,0.01980967,0.000838641],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530001,0.03791132,0.000006842384,0.006469309,0.0003743175,0.001537726,0.0005626391,0.00005492297,0.00008287719],"genre_scores_gemma":[0.9931498,0.002225293,0.0001688692,0.0004131375,0.0003480586,0.003189644,0.00002043432,0.00009932081,0.0003854233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6436617,"threshold_uncertainty_score":0.9999998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08569701664852465,"score_gpt":0.4448074994330611,"score_spread":0.3591104827845364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}