{"id":"W4220720592","doi":"10.1097/aln.0000000000004199","title":"Referral Indications for Malignant Hyperthermia Susceptibility Diagnostics in Patients without Adverse Anesthetic Events in the Era of Next-generation Sequencing","year":2022,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Malignant hyperthermia; Referral; Adverse effect; Anesthetic; Complication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005154977,0.00008617669,0.0001201855,0.00006078215,0.0001078843,0.000001703982,0.0001379884,0.00008574579,0.0000156098],"category_scores_gemma":[0.0001533038,0.00007130145,0.00004781472,0.0001225871,0.00004830715,0.000005639851,0.0000299916,0.0001144801,9.920595e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005024316,"about_ca_system_score_gemma":0.00007882169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007541039,"about_ca_topic_score_gemma":0.0001725363,"domain_scores_codex":[0.9988424,0.0004175896,0.0002720019,0.0002273126,0.00009674198,0.0001439338],"domain_scores_gemma":[0.9995377,0.00004807085,0.0001215031,0.0002208707,0.00005568198,0.00001619349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002307484,0.000262054,0.9727063,0.00001069115,0.000005701412,0.00000113887,0.000875982,0.003948849,0.0204454,0.0001710525,0.0001331748,0.001208958],"study_design_scores_gemma":[0.00134339,0.001241969,0.9898393,0.000007538552,0.00001229401,0.00001766426,0.001127663,0.001706031,0.002875442,0.0003512633,0.001329083,0.0001483504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990857,0.0000523476,0.00006142353,0.0001396698,0.0001196035,0.0005177291,0.00000929884,0.000003210221,0.0000110659],"genre_scores_gemma":[0.9984416,0.00002424643,0.00007851407,0.000480021,0.00005941661,0.0002218422,0.0006617623,0.000009774751,0.00002284661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01756996,"threshold_uncertainty_score":0.2907588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04548354786286718,"score_gpt":0.2628437969457804,"score_spread":0.2173602490829132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}