{"id":"W4220720592","doi":"10.1097/aln.0000000000004199","title":"Referral Indications for Malignant Hyperthermia Susceptibility Diagnostics in Patients without Adverse Anesthetic Events in the Era of Next-generation Sequencing","year":2022,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Malignant hyperthermia; Referral; Adverse effect; Anesthetic; Complication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00110445,0.0001892565,0.0003311675,0.0008999903,0.0004916096,0.0006893376,0.0003942728,0.0004396598,0.002081752],"category_scores_gemma":[0.003640963,0.0001936189,0.0004003166,0.001523598,0.0002363541,0.0004888116,0.000635806,0.0003869732,0.000316739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625236,"about_ca_system_score_gemma":0.0005533632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004378373,"about_ca_topic_score_gemma":0.00743266,"domain_scores_codex":[0.9989297,0.0002124598,0.0001748831,0.0003653601,0.0001667167,0.0001508465],"domain_scores_gemma":[0.9965946,0.0006446262,0.00199673,0.0001806428,0.0003074784,0.0002758832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008721765,0.00001039765,0.9976465,0.00002062334,0.00001439464,0.0003260756,0.00007555419,0.00002399142,0.0002092506,0.00001683881,0.0002664011,0.001302719],"study_design_scores_gemma":[0.000008817819,0.00006820478,0.9960974,0.00004673728,0.00004176649,0.002551671,0.0002531528,0.0001973565,0.000119522,0.00003034412,0.0005782409,0.000006749692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970217,0.0007882157,0.0002606566,0.0001060106,0.00001323482,0.00002669971,0.001100417,0.00001027577,0.0006727293],"genre_scores_gemma":[0.9981555,0.0003322057,0.000313032,0.0001247139,0.00002414048,0.00002892937,0.0008757423,0.000005892681,0.0001396447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004378373,"threshold_uncertainty_score":0.008705795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04548354786286718,"score_gpt":0.2628437969457804,"score_spread":0.2173602490829132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}