{"id":"W4220721294","doi":"10.1007/s11010-021-04337-5","title":"Identifying simultaneous matrix metalloproteinases/soluble epoxide hydrolase inhibitors","year":2022,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Epoxide hydrolase 2; Chemistry; Matrix metalloproteinase; Zymography; Recombinant DNA; Enzyme; Matrix metalloproteinase inhibitor; Biochemistry; Pharmacology; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004962282,0.0005791164,0.0004912784,0.0005453192,0.0002350231,0.0008346885,0.0003888323,0.0004008875,0.00269041],"category_scores_gemma":[0.0006725848,0.0003894145,0.0004050134,0.000355997,0.0002462582,0.0006593302,0.0003337949,0.001100876,0.001138627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004609186,"about_ca_system_score_gemma":0.0005567853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005078749,"about_ca_topic_score_gemma":0.001428013,"domain_scores_codex":[0.9996114,0.00004045788,0.00003102128,0.00009154543,0.0001165694,0.0001090799],"domain_scores_gemma":[0.9997031,0.00007109401,0.00004905536,0.00003312156,0.00008002666,0.00006350112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000290137,0.00007410418,0.0003095487,0.00003082624,0.00001302883,0.00005035065,0.000007899086,0.0000885692,0.9949381,0.0002584147,0.0001103264,0.003828573],"study_design_scores_gemma":[0.0000255141,0.0001609617,0.001544325,0.000002815968,0.0000227302,0.0001761445,0.00000990258,0.00111586,0.9947196,0.00008347493,0.002135197,0.000003431335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8567272,0.0089661,0.1216946,0.0005993888,0.0004441236,0.0005326857,0.001480864,0.0005610144,0.00899411],"genre_scores_gemma":[0.904958,0.003955389,0.07293237,0.000215188,0.0001765331,0.0003399447,0.002616167,0.0001238417,0.01468266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00269041,"threshold_uncertainty_score":0.009000301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006059443193717922,"score_gpt":0.2379345644378916,"score_spread":0.2318751212441736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}