{"id":"W4220731413","doi":"10.2139/ssrn.4039857","title":"Blockers of PCSK9 Ribosome Synthesis: Computational Predictions and in Vitro Confirmation","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"PCSK9; In vitro; Chemistry; Pharmacology; Medicine; Internal medicine; Biochemistry; LDL receptor; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007541275,0.001312338,0.002020641,0.0005439664,0.0005922452,0.001332528,0.001359603,0.0008016113,0.0062372],"category_scores_gemma":[0.002544851,0.0004409327,0.001140365,0.0005790105,0.0003744224,0.0006053085,0.0003370542,0.001828164,0.001673308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001059373,"about_ca_system_score_gemma":0.00124228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00443237,"about_ca_topic_score_gemma":0.005275844,"domain_scores_codex":[0.9996501,0.000118428,0.00002410305,0.00006923764,0.00007774085,0.00006041446],"domain_scores_gemma":[0.9980288,0.001484375,0.0001371524,0.00008463521,0.000186634,0.00007833243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002805603,0.001195947,0.00710992,0.001538607,0.0005911036,0.0009407834,0.000112572,0.8857086,0.04648869,0.0175774,0.007348451,0.02858228],"study_design_scores_gemma":[0.0002670778,0.0006343132,0.000592998,0.00005465471,0.0002862787,0.0001003829,0.00005954461,0.9603158,0.03209615,0.003087319,0.002455674,0.00004988865],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9135726,0.004503561,0.05361604,0.001073336,0.0003881981,0.0001219154,0.006638494,0.002339358,0.01774655],"genre_scores_gemma":[0.9802801,0.0009455577,0.01364084,0.0001736252,0.00004995871,0.00008630734,0.003343916,0.0001874073,0.001292102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0062372,"threshold_uncertainty_score":0.02086556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006669576837202041,"score_gpt":0.2298896840802509,"score_spread":0.2232201072430489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}