{"id":"W4220732249","doi":"10.1101/2022.03.13.484119","title":"N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Lundbeckfonden; H. Lundbeck A/S; Israel Science Foundation; Novo Nordisk Fonden; Medical Research Council; Novo Nordisk","keywords":"Excitotoxicity; Neuroprotection; Calpain; Biology; Cell biology; Glutamate receptor; Neuroscience; Proteolysis; Programmed cell death; NMDA receptor; Biochemistry; Receptor; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447281,0.0003640956,0.0003209527,0.0004004486,0.0001293175,0.0003040362,0.0002106104,0.0006151036,0.0005051828],"category_scores_gemma":[0.0002022264,0.00016898,0.0003269877,0.0001883165,0.0002514403,0.0003433345,0.0002351428,0.0006863974,0.0002539297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988163,"about_ca_system_score_gemma":0.0001126899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002588175,"about_ca_topic_score_gemma":0.0005134483,"domain_scores_codex":[0.9999158,0.000008479875,0.00001062943,0.00002166761,0.00002845192,0.00001495569],"domain_scores_gemma":[0.999851,0.00001500655,0.00005686794,0.00001301159,0.00004217821,0.00002195576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005141,0.000008476791,0.0005845852,0.00006427427,0.00001151855,0.00009084817,0.00001073686,0.00002194929,0.9970502,0.00004775656,0.00006298356,0.001946063],"study_design_scores_gemma":[0.00002760855,0.0004548902,0.06207029,0.00003711136,0.0001239365,0.002375168,0.000104424,0.001676447,0.927191,0.0004330137,0.005481618,0.00002434918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562491,0.01828093,0.02135385,0.00059062,0.0002492414,0.0001095847,0.001141621,0.0001630085,0.0018622],"genre_scores_gemma":[0.9679458,0.01146171,0.01525544,0.0007130369,0.00009060131,0.00009443813,0.001203664,0.00005296938,0.003182402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006151036,"threshold_uncertainty_score":0.00168997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007756203143249939,"score_gpt":0.1976375404696662,"score_spread":0.1898813373264163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}