{"id":"W4220735712","doi":"10.1016/j.cjco.2022.03.003","title":"Real-World Insights Into Evolocumab Use in Patients With Hyperlipidemia: Canadian Analysis From the ZERBINI Study","year":2022,"lang":"en","type":"article","venue":"CJC Open","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cardiome (Canada); Université Laval; Centre hospitalier universitaire de Québec; Amgen (Canada); Cambridge Cardiac Care Centre; Island Health; University of British Columbia; McMaster University","funders":"Amgen Canada; Sanofi; Kowa Company; Amgen; Boehringer Ingelheim; Novo Nordisk; Bayer; AstraZeneca; Regeneron Pharmaceuticals; Novartis; HLS Therapeutics; Pfizer","keywords":"Evolocumab; Medicine; PCSK9; Internal medicine; Statin; Alirocumab; Adverse effect; Hyperlipidemia; Apolipoprotein B; Gastroenterology; Cholesterol; Lipoprotein; Endocrinology; Diabetes mellitus; Apolipoprotein A1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001458649,0.000360427,0.0005448893,0.001546718,0.001224424,0.001190593,0.0007528063,0.0004435661,0.001810268],"category_scores_gemma":[0.004181734,0.0002503108,0.0008086574,0.005686635,0.0004539373,0.0003339843,0.0006377614,0.0007087127,0.0001955574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008980437,"about_ca_system_score_gemma":0.01313207,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.920188,"about_ca_topic_score_gemma":0.9437718,"domain_scores_codex":[0.9985808,0.0001669007,0.0001301523,0.0002356601,0.0005723147,0.0003141438],"domain_scores_gemma":[0.9950529,0.0003884303,0.001795683,0.0002442486,0.001620684,0.0008981236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003016097,0.00001467346,0.9948063,0.00007000684,0.0001712014,0.00005799964,0.0001594445,0.00005940457,0.00006092232,0.00009023025,0.0013916,0.002816369],"study_design_scores_gemma":[0.00003748841,0.00001762846,0.9980937,0.00004688761,0.0001040509,0.00007520358,0.00021739,0.000135825,0.0000215585,0.00001607746,0.001221742,0.00001251369],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719854,0.004004199,0.0001181361,0.0007817237,0.00002148723,0.000069945,0.01935437,0.000009640234,0.00365524],"genre_scores_gemma":[0.9909339,0.001535675,0.0001780056,0.0001962833,0.0000185165,0.00002204545,0.006803558,0.000005801865,0.0003063045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07981205,"threshold_uncertainty_score":0.1605641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01880120690716842,"score_gpt":0.2718837726999043,"score_spread":0.2530825657927359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}