{"id":"W4220738012","doi":"10.1021/acsinfecdis.1c00482","title":"Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant","year":2022,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; U.S. Department of Health and Human Services","keywords":"Antibiotics; Pentamidine; Biology; Acinetobacter baumannii; Microbiology; Cytotoxicity; Toxicity; Efflux; Bacteria; Pathogen; Pharmacology; Chemistry; Biochemistry; Medicine; In vitro; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792688,0.0005223968,0.0002783307,0.0002463764,0.0001165243,0.000259013,0.0003083819,0.000347219,0.001592808],"category_scores_gemma":[0.0001374076,0.0001548097,0.0002100018,0.0001300782,0.0002214303,0.0003093162,0.0001671252,0.0008425649,0.0002447802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002755215,"about_ca_system_score_gemma":0.0002949889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005246078,"about_ca_topic_score_gemma":0.001004979,"domain_scores_codex":[0.9999157,0.00001625271,0.000006045037,0.00001761445,0.0000182386,0.00002606764],"domain_scores_gemma":[0.9999142,0.00001106641,0.00002538984,0.000007895806,0.000013405,0.00002809809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006915234,0.0007209454,0.0001639647,0.0002555482,0.00002010466,0.0001335645,0.00003264441,0.001239132,0.9814097,0.0006367201,0.0004875816,0.01420858],"study_design_scores_gemma":[0.0003496276,0.02581932,0.001654113,0.00003685796,0.00007650882,0.0005670945,0.00003218008,0.001915894,0.9538893,0.0002437918,0.0153981,0.00001721902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670437,0.008249488,0.01499428,0.0005058308,0.0001555544,0.0007223603,0.001318666,0.0002483432,0.006761903],"genre_scores_gemma":[0.9860026,0.004358247,0.006026832,0.0001568963,0.00002113478,0.0001960012,0.0006964409,0.0000149647,0.002526909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592808,"threshold_uncertainty_score":0.005328476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115224925745582,"score_gpt":0.2696000928799716,"score_spread":0.2584478436225158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}