{"id":"W4220738012","doi":"10.1021/acsinfecdis.1c00482","title":"Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant","year":2022,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; U.S. Department of Health and Human Services","keywords":"Antibiotics; Pentamidine; Biology; Acinetobacter baumannii; Microbiology; Cytotoxicity; Toxicity; Efflux; Bacteria; Pathogen; Pharmacology; Chemistry; Biochemistry; Medicine; In vitro; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556387,0.0001441525,0.000209749,0.00005687663,0.0002223101,0.00002247468,0.0001503536,0.00004631658,0.00005133696],"category_scores_gemma":[0.0001391199,0.0001439801,0.00007475482,0.00008925395,0.0001484577,0.000005649164,0.0004119812,0.0000725061,0.000002743304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003284002,"about_ca_system_score_gemma":0.0001417694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001420104,"about_ca_topic_score_gemma":0.00005690534,"domain_scores_codex":[0.9988376,0.00009059817,0.0003440318,0.0003505277,0.0001887156,0.0001885226],"domain_scores_gemma":[0.9993967,0.00002714455,0.0001622771,0.0002750377,0.00005345542,0.00008535288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001547568,0.0006028665,0.7715544,0.0001229466,0.0002131285,0.00001343696,0.000114675,0.00003377128,0.221013,0.00006043183,0.0007463577,0.005370306],"study_design_scores_gemma":[0.0006579642,0.0003896794,0.9594393,0.00002527895,0.00008717178,0.00003597383,0.0003235625,0.00001278912,0.03726263,0.00009510641,0.001438135,0.0002324217],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976368,0.001478973,0.0001382287,0.00001806793,0.0002362797,0.0001984834,0.00006285733,0.00001995301,0.0002103759],"genre_scores_gemma":[0.9991366,0.000236399,0.0001315579,0.00007915038,0.00005788667,0.00001148962,0.000145067,0.00001854198,0.0001833049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1878849,"threshold_uncertainty_score":0.5871338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115224925745582,"score_gpt":0.2696000928799716,"score_spread":0.2584478436225158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}