{"id":"W4220738363","doi":"10.1053/j.gastro.2022.02.049","title":"Precision Medicine in Inflammatory Bowel Diseases: Challenges and Considerations for the Path Forward","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Takeda Canada; AOP Orphan; MedImmune; Astellas Pharma Canada; Diagnostic Services Manitoba; AbbVie Canada; Nippon Kayaku; Amgen; Boehringer Ingelheim; Gilead Sciences; Arrien Pharmaceuticals; Novartis; Dr. Falk Pharma; Pfizer; Shire; AstraZeneca; Eli Lilly and Company; Schering-Plough; Abbott Laboratories","keywords":"Inflammatory Bowel Diseases; Path (computing); Medicine; Intensive care medicine; Inflammatory bowel disease; Computer science; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09193078,0.001993267,0.007434785,0.003091618,0.003767271,0.01379551,0.006021004,0.01919752,0.01429495],"category_scores_gemma":[0.07696006,0.001132047,0.003268232,0.001995025,0.02013165,0.02913008,0.009693213,0.02615789,0.003574386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006680544,"about_ca_system_score_gemma":0.02432087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00505882,"about_ca_topic_score_gemma":0.007519071,"domain_scores_codex":[0.977417,0.01149544,0.001918182,0.001973473,0.005633817,0.001562036],"domain_scores_gemma":[0.8214072,0.1401377,0.003976198,0.005225306,0.02020327,0.00905019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001349005,0.0004880271,0.003175889,0.009164171,0.0008088302,0.000940992,0.001269257,0.004245797,0.00183017,0.3204613,0.2391663,0.4171003],"study_design_scores_gemma":[0.0002542434,0.0008628949,0.001814302,0.009893687,0.0003478609,0.001150058,0.002631422,0.002871573,0.0006282605,0.5582558,0.4209838,0.0003062989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0006930009,0.4832627,0.01104589,0.495252,0.006204012,0.00003880502,0.0001708509,0.0001661625,0.003166631],"genre_scores_gemma":[0.04582679,0.6963648,0.05184361,0.1512327,0.05101132,0.0003843701,0.0004329064,0.0001530572,0.002750405],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.09193078,"threshold_uncertainty_score":0.4861823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155140025805866,"score_gpt":0.2409058071247152,"score_spread":0.2293544068666565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}