{"id":"W4220739427","doi":"10.1101/2022.03.14.484313","title":"Imaging tools generated by CRISPR/Cas9 tagging reveal cytokinetic diversity in mammalian cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Concordia University; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Cytokinesis; Cell biology; Biology; Mitosis; RHOA; Live cell imaging; Cell division; CRISPR; Cell; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003765636,0.0002803088,0.000327535,0.0004438353,0.0002653694,0.0006800256,0.0003479721,0.0005513776,0.001354856],"category_scores_gemma":[0.0002437266,0.0002766552,0.000270975,0.0002053414,0.0003947801,0.0003212689,0.0005554762,0.0009433217,0.0007195851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004595194,"about_ca_system_score_gemma":0.0001862553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005368848,"about_ca_topic_score_gemma":0.0007711278,"domain_scores_codex":[0.9997813,0.00002076214,0.00002119525,0.00006834006,0.00007746234,0.00003087805],"domain_scores_gemma":[0.9997583,0.00006820763,0.00007103972,0.00004454451,0.00002485272,0.00003302403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001846085,0.00000480502,0.0001157811,0.00001962539,0.000003925477,0.00005140701,0.00001447249,0.00015853,0.9977161,0.0004096919,0.00008104258,0.001406232],"study_design_scores_gemma":[0.000007619036,0.00001659137,0.0009067776,0.000007390654,0.000006168118,0.0002124884,0.00001384043,0.002083711,0.9907883,0.000198839,0.005752475,0.000005857935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7699667,0.001875587,0.2135359,0.0005490685,0.0001942388,0.0001259617,0.002465998,0.002596058,0.008690423],"genre_scores_gemma":[0.8832572,0.001320748,0.1055156,0.0002854339,0.00003211288,0.0001372496,0.001827695,0.0006483673,0.006975547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354856,"threshold_uncertainty_score":0.004532397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109560571378103,"score_gpt":0.213690320260313,"score_spread":0.2027342631225027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}