{"id":"W4220739578","doi":"10.3390/antiox11020243","title":"Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1","year":2022,"lang":"en","type":"article","venue":"Antioxidants","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Lawson Health Research Institute","keywords":"KEAP1; Ubiquitin ligase; Oxidative stress; Ubiquitin; Cell biology; Protein folding; Chemistry; Transcription factor; Endoplasmic-reticulum-associated protein degradation; Oxidative phosphorylation; Unfolded protein response; Proteostasis; Proteasome; Biochemistry; Biology; Endoplasmic reticulum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001595552,0.0001107609,0.0001395331,0.0000507117,0.0004207951,0.000008880362,0.0001169142,0.00005042654,0.00001225658],"category_scores_gemma":[0.00004560637,0.000116957,0.00003115072,0.00006220506,0.00006063832,0.0000109644,0.001897779,0.00007770013,3.395786e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001130855,"about_ca_system_score_gemma":0.00001978492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002382633,"about_ca_topic_score_gemma":0.00001382191,"domain_scores_codex":[0.9992298,0.00006444935,0.0001882649,0.0002404562,0.0001337365,0.0001432747],"domain_scores_gemma":[0.9995928,0.00001443274,0.0001439093,0.0001482319,0.00005208728,0.00004858111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005868092,0.00004373772,0.004132078,0.00003666353,0.00001945838,9.91211e-7,0.0007898569,0.000005486834,0.9923665,0.00003923449,0.00007423345,0.002433059],"study_design_scores_gemma":[0.0005248268,0.0002121009,0.007164105,0.00001806755,0.00001296021,0.00001058501,0.0008607761,0.00006299027,0.9899589,0.0004055459,0.0006349742,0.0001341368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982563,0.0007701534,0.0002652348,0.00006356878,0.0000542806,0.0001546004,0.000103431,0.000005389187,0.0003270468],"genre_scores_gemma":[0.99907,0.000343933,0.0002811778,0.0000886783,0.00004140968,0.00001223081,0.0001073729,0.00001147756,0.00004371785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003032028,"threshold_uncertainty_score":0.4769367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261838256290608,"score_gpt":0.2491294900719674,"score_spread":0.2365111075090613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}