{"id":"W4220739578","doi":"10.3390/antiox11020243","title":"Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1","year":2022,"lang":"en","type":"article","venue":"Antioxidants","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Lawson Health Research Institute","keywords":"KEAP1; Ubiquitin ligase; Oxidative stress; Ubiquitin; Cell biology; Protein folding; Chemistry; Transcription factor; Endoplasmic-reticulum-associated protein degradation; Oxidative phosphorylation; Unfolded protein response; Proteostasis; Proteasome; Biochemistry; Biology; Endoplasmic reticulum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002186684,0.0002261489,0.0001915147,0.0001940491,0.0001959198,0.0002223262,0.0001371562,0.0002074853,0.0005532712],"category_scores_gemma":[0.0001373418,0.0001102001,0.0002233276,0.0001872465,0.0001913654,0.0002719674,0.0002054062,0.0003183417,0.000122874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137665,"about_ca_system_score_gemma":0.0001433051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005326417,"about_ca_topic_score_gemma":0.0006849415,"domain_scores_codex":[0.9998657,0.00002354754,0.00001508299,0.00003599347,0.00003480953,0.00002485963],"domain_scores_gemma":[0.9998524,0.00001726894,0.00005303186,0.00002194956,0.00002755424,0.0000277099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008104963,0.00001042358,0.0005213153,0.00002400793,0.000007781406,0.00004023248,0.00002993648,0.00003386803,0.9988777,0.00004756758,0.000009204869,0.0003168628],"study_design_scores_gemma":[0.000004274914,0.0001146629,0.01711051,0.00000464774,0.00001203396,0.0004134265,0.00008457395,0.0005612475,0.980615,0.00009680568,0.0009776721,0.000005060398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966376,0.0007600572,0.001919404,0.00004458569,0.00001062541,0.00001219266,0.0002787132,0.00001698306,0.0003199219],"genre_scores_gemma":[0.9964345,0.0003241917,0.001684526,0.00003264857,0.000003307473,0.00001344595,0.0003790775,0.000008023761,0.001120256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005532712,"threshold_uncertainty_score":0.001850903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261838256290608,"score_gpt":0.2491294900719674,"score_spread":0.2365111075090613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}