{"id":"W4220741140","doi":"10.1038/s41598-022-06796-2","title":"Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Robarts Research Institute; Canadian Institutes of Health Research; London Health Sciences Foundation","keywords":"Serous ovarian cancer; Serous fluid; Spheroid; Ovarian cancer; Cancer research; Oncology; Cancer; Medicine; Internal medicine; Computer science; Biology; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789978,0.0002858969,0.0003822531,0.0003042192,0.0001814276,0.0002353725,0.0001482418,0.000305142,0.001098715],"category_scores_gemma":[0.00007310975,0.0001650248,0.0003380669,0.0002361937,0.0002693587,0.0001948797,0.0001707834,0.0008355571,0.0002854959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000318156,"about_ca_system_score_gemma":0.000272923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104856,"about_ca_topic_score_gemma":0.001454444,"domain_scores_codex":[0.9998531,0.00002005982,0.00001913512,0.00003171403,0.00003997514,0.0000359282],"domain_scores_gemma":[0.9998655,0.00001896491,0.00003688852,0.00001596558,0.000009168872,0.00005350735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002568403,0.00006566998,0.0001928476,0.00006963938,0.000007794471,0.00008130208,0.00004226034,0.0001525058,0.9984053,0.00006592141,0.00008829147,0.0005717148],"study_design_scores_gemma":[0.00009634146,0.001270715,0.006370637,0.00001494817,0.00003534908,0.0003748572,0.0001511714,0.003339497,0.9850771,0.0001013599,0.003155097,0.00001299512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937152,0.001280686,0.002255378,0.000154827,0.00008408252,0.00006214543,0.001189214,0.0001518486,0.001106542],"genre_scores_gemma":[0.9940079,0.0008023072,0.001955476,0.00004755403,0.000008566859,0.0001087234,0.0008776904,0.00001991704,0.002171792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098715,"threshold_uncertainty_score":0.00367558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911782318499632,"score_gpt":0.2556982811071351,"score_spread":0.2365804579221388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}