{"id":"W4220744146","doi":"10.3389/fonc.2022.839536","title":"Senecavirus A as an Oncolytic Virus: Prospects, Challenges and Development Directions","year":2022,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Science Foundation of Heilongjiang Province; Department of Education, Heilongjiang Province; National Natural Science Foundation of China","keywords":"Oncolytic virus; Virotherapy; Picornavirus; Genome; Immunotherapy; Virus; Cancer therapy; Computational biology; Biology; Virology; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008783743,0.0004700883,0.001283063,0.0004481688,0.0002028371,0.00002310018,0.0005311419,0.0006835644,0.0001233905],"category_scores_gemma":[0.0001124934,0.0004732742,0.0001428698,0.000228281,0.0001972419,0.000006313166,0.0004322509,0.0006834764,0.00002076994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008668317,"about_ca_system_score_gemma":0.002764476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002653381,"about_ca_topic_score_gemma":0.001825897,"domain_scores_codex":[0.9965564,0.0009837134,0.0005622979,0.001065503,0.0002454335,0.0005866641],"domain_scores_gemma":[0.9988571,0.00005970065,0.0002238331,0.0006118734,0.00003403053,0.0002134042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003280076,0.0003403868,0.000006044944,0.0007930753,0.0002711593,0.00007703559,0.0003214787,0.000001274326,0.00003636687,0.00001253677,0.001034547,0.9967781],"study_design_scores_gemma":[0.0005494829,0.004452684,0.00000643889,0.0001799833,0.00007504271,0.0001388293,0.0003243039,0.000002419386,0.0001406424,0.00006948636,0.993579,0.0004817447],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005097296,0.9946391,0.00001650639,0.00004474381,0.000821749,0.001205708,0.00002861295,0.00002996933,0.002703907],"genre_scores_gemma":[0.00001025251,0.9946229,0.002070031,0.0001112729,0.0002685254,0.001594396,0.0003447397,0.0001085458,0.0008692674],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9962963,"threshold_uncertainty_score":0.9997719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06774764543636094,"score_gpt":0.3794139240490263,"score_spread":0.3116662786126654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}