{"id":"W4220744146","doi":"10.3389/fonc.2022.839536","title":"Senecavirus A as an Oncolytic Virus: Prospects, Challenges and Development Directions","year":2022,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Science Foundation of Heilongjiang Province; Department of Education, Heilongjiang Province; National Natural Science Foundation of China","keywords":"Oncolytic virus; Virotherapy; Picornavirus; Genome; Immunotherapy; Virus; Cancer therapy; Computational biology; Biology; Virology; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005371118,0.000575792,0.000849259,0.001607533,0.0002240258,0.0010594,0.0005925391,0.0009021311,0.002736294],"category_scores_gemma":[0.0004355367,0.0002571861,0.0003709999,0.001415737,0.0003856707,0.001471095,0.0004806757,0.001607,0.001329944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004923032,"about_ca_system_score_gemma":0.001116431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008275444,"about_ca_topic_score_gemma":0.001420647,"domain_scores_codex":[0.9998847,0.00002037634,0.00001369277,0.00002136215,0.00004504933,0.00001481362],"domain_scores_gemma":[0.9998012,0.00008743603,0.00002364686,0.000005730808,0.00005697074,0.00002507685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008632074,0.00009854641,0.0001917611,0.01590334,0.000059129,0.0002440564,0.00007120038,0.0006457829,0.006877172,0.008611934,0.0193743,0.9478365],"study_design_scores_gemma":[0.0000115376,0.000119365,0.0003394934,0.001811332,0.00006106316,0.0008180077,0.00004733518,0.0001492605,0.001325442,0.002243803,0.9930577,0.00001549023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002098479,0.9980329,0.0002248351,0.0002549635,0.0001391467,0.000004207086,0.00001307933,0.00000798415,0.001113093],"genre_scores_gemma":[0.0007340218,0.9983912,0.0002246371,0.000111789,0.00006885367,0.000004425162,0.00002074986,0.000001342281,0.0004429355],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002736294,"threshold_uncertainty_score":0.009153843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06774764543636094,"score_gpt":0.3794139240490263,"score_spread":0.3116662786126654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}