{"id":"W4220744522","doi":"10.1016/s2666-6367(22)00583-8","title":"Cost-Effectiveness of Brexucabtagene Autoleucel Versus Best Supportive Care for the Treatment of Relapsed/ Refractory Mantle Cell Lymphoma Following Treatment with a Bruton’s Tyrosine Kinase Inhibitor in Canada","year":2022,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Mantle cell lymphoma; Refractory (planetary science); Bruton's tyrosine kinase; Ibrutinib; Internal medicine; Lymphoma; Oncology; Cancer research; Tyrosine kinase; Leukemia; Metallurgy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005679987,0.0003150297,0.0007658858,0.000523727,0.0004555923,0.00100059,0.0007502382,0.0007005449,0.002917985],"category_scores_gemma":[0.002220878,0.0001824534,0.00130334,0.0008503626,0.0006091212,0.0003769046,0.0004997537,0.0008897866,0.00009899061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0306663,"about_ca_system_score_gemma":0.02017427,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7233565,"about_ca_topic_score_gemma":0.852797,"domain_scores_codex":[0.9993058,0.0002282707,0.00004849093,0.00006366723,0.0001266418,0.0002271098],"domain_scores_gemma":[0.9988201,0.000197244,0.0001988348,0.00001765485,0.0001482548,0.0006178876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4042801,0.006743223,0.1475545,0.002848547,0.005729109,0.001601187,0.0005712743,0.0357821,0.004353088,0.003983001,0.01057651,0.3759775],"study_design_scores_gemma":[0.0558343,0.06732212,0.7999786,0.001462022,0.01155525,0.001700368,0.002473804,0.04073844,0.002180411,0.001328357,0.01513797,0.0002883761],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850399,0.009413732,0.0001338013,0.001674913,0.00007747165,0.0001815969,0.0008357461,0.00001443162,0.002628351],"genre_scores_gemma":[0.9966868,0.002011388,0.0001634138,0.0001861974,0.00002254038,0.00002608902,0.0003224018,0.000003060846,0.0005781672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2766435,"threshold_uncertainty_score":0.5565453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03384285600326573,"score_gpt":0.2919828620676587,"score_spread":0.258140006064393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}