{"id":"W4220744522","doi":"10.1016/s2666-6367(22)00583-8","title":"Cost-Effectiveness of Brexucabtagene Autoleucel Versus Best Supportive Care for the Treatment of Relapsed/ Refractory Mantle Cell Lymphoma Following Treatment with a Bruton’s Tyrosine Kinase Inhibitor in Canada","year":2022,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Mantle cell lymphoma; Refractory (planetary science); Bruton's tyrosine kinase; Ibrutinib; Internal medicine; Lymphoma; Oncology; Cancer research; Tyrosine kinase; Leukemia; Metallurgy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477475,0.0001933236,0.0003899285,0.00009898774,0.0001265964,0.000005321662,0.00005912883,0.00003416313,0.0001121166],"category_scores_gemma":[9.095139e-7,0.0001331072,0.0001134372,0.0001925216,0.00005032465,0.00003003257,0.000003363122,0.00005357025,1.574737e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001261533,"about_ca_system_score_gemma":0.001135141,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2058239,"about_ca_topic_score_gemma":0.100803,"domain_scores_codex":[0.9987522,0.0001829972,0.0002508063,0.000255685,0.0003432506,0.0002150292],"domain_scores_gemma":[0.9991482,0.0004172235,0.00009436029,0.0002105989,0.00005889327,0.00007073708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.08424757,0.002730175,0.01072134,0.0006609875,0.00066761,0.0005450115,0.01863846,0.0004060016,0.7539477,0.0000120571,0.000002980021,0.1274201],"study_design_scores_gemma":[0.06193531,0.01710967,0.00613467,0.00009177501,0.0003155512,0.00001501449,0.009321208,0.000174062,0.898964,0.000001362542,0.005779471,0.000157919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893752,0.007237012,0.00009355329,0.00003569346,0.0001372016,0.002626603,0.0003556436,0.000007205364,0.0001319122],"genre_scores_gemma":[0.9933897,0.004890814,0.00003692808,0.00001283232,0.00001910279,0.0007489689,0.0005279273,0.00003481567,0.0003388922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1450163,"threshold_uncertainty_score":0.9156049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03384285600326573,"score_gpt":0.2919828620676587,"score_spread":0.258140006064393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}