{"id":"W4220747142","doi":"10.1016/j.cmet.2021.12.021","title":"Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state","year":2022,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Breakthrough T1D Canada; Medical Research Council; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Alberta Innovates; National Institutes of Health; Syddansk Universitet; Canada Research Chairs; University of Alberta","keywords":"Exocytosis; Cell biology; Biology; Type 2 diabetes; Downregulation and upregulation; Cell; Cell type; Transcriptome; Electrophysiology; Progenitor cell; Phenotype; Internal medicine; Endocrinology; Stem cell; Secretion; Diabetes mellitus; Neuroscience; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002818304,0.0001697099,0.0004023039,0.000293004,0.00007388953,0.000012466,0.00007933103,0.00004876337,0.001095587],"category_scores_gemma":[0.00001922914,0.0001609283,0.00009763292,0.0005494071,0.00001713555,0.00005677588,0.0000764597,0.0002038818,0.000133373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000846928,"about_ca_system_score_gemma":0.00009288528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004271909,"about_ca_topic_score_gemma":0.000001034315,"domain_scores_codex":[0.9985673,0.0001073427,0.0003905419,0.0002885857,0.0003458258,0.0003003772],"domain_scores_gemma":[0.9992529,0.000043008,0.00014074,0.0003171452,0.0000977356,0.0001484828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006454838,0.0007317485,0.006779621,0.0002393395,0.00002847188,0.000005511165,0.002427801,0.0005238591,0.9835904,0.000005637763,0.003906609,0.001115557],"study_design_scores_gemma":[0.003827006,0.001554683,0.1043235,0.00002215743,0.000261371,0.000001535406,0.0007798323,0.0008696245,0.8367168,0.0001607282,0.0511906,0.0002921748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928246,0.002546322,0.00003635361,0.0001495397,0.001048145,0.0006016697,0.00003041882,0.00004545035,0.002717471],"genre_scores_gemma":[0.9938152,0.00008612398,0.0005035006,0.001838638,0.00008882589,0.0000811882,0.00006633882,0.0000296499,0.003490561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1468736,"threshold_uncertainty_score":0.9998176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009986642800623264,"score_gpt":0.2197213259815723,"score_spread":0.209734683180949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}