{"id":"W4220747142","doi":"10.1016/j.cmet.2021.12.021","title":"Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state","year":2022,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Breakthrough T1D Canada; Medical Research Council; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Alberta Innovates; National Institutes of Health; Syddansk Universitet; Canada Research Chairs; University of Alberta","keywords":"Exocytosis; Cell biology; Biology; Type 2 diabetes; Downregulation and upregulation; Cell; Cell type; Transcriptome; Electrophysiology; Progenitor cell; Phenotype; Internal medicine; Endocrinology; Stem cell; Secretion; Diabetes mellitus; Neuroscience; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145882,0.0002289306,0.0002805815,0.000572387,0.0002113319,0.0006035296,0.0001873421,0.0002363998,0.002069751],"category_scores_gemma":[0.000276449,0.0001691878,0.0002467108,0.0004096479,0.0002535105,0.0003125723,0.0003588745,0.0007409412,0.0003193089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001699617,"about_ca_system_score_gemma":0.0001205576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003062554,"about_ca_topic_score_gemma":0.0001881674,"domain_scores_codex":[0.9998535,0.00002848375,0.00001731229,0.0000452424,0.00002358456,0.00003184879],"domain_scores_gemma":[0.9996572,0.00004504913,0.0001216979,0.00004414571,0.00002631389,0.0001056081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004361579,0.0001594543,0.04944182,0.00005922341,0.00005550207,0.0005139975,0.0001504176,0.00006845444,0.9380292,0.0002687766,0.0001056383,0.006785929],"study_design_scores_gemma":[0.00004792891,0.001050015,0.8260307,0.00002469697,0.0001153369,0.002503402,0.0003972827,0.0004836141,0.1667598,0.0007385804,0.00182826,0.00002034773],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971194,0.001309303,0.0006326791,0.0000345394,0.00001969009,0.000005251771,0.0001994342,0.00001749688,0.0006622326],"genre_scores_gemma":[0.9982261,0.0005859382,0.0002596087,0.00001998021,0.00001627413,0.00001027221,0.0002691976,0.00001282074,0.0005997389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002069751,"threshold_uncertainty_score":0.006923974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009986642800623264,"score_gpt":0.2197213259815723,"score_spread":0.209734683180949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}