{"id":"W4220752783","doi":"10.2337/db21-0918","title":"The Role of Long Noncoding RNA MALAT1 in Diabetic Polyneuropathy and the Impact of Its Silencing in the Dorsal Root Ganglion by a DNA/RNA Heteroduplex Oligonucleotide","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Daiichi Sankyo Company; Daiichi Sankyo Europe; Ono Pharmaceutical; Mitsubishi Tanabe Pharma Corporation; Ionis Pharmaceuticals; Toray Industries; Japan Agency for Medical Research and Development","keywords":"Dorsal root ganglion; Heteroduplex; Polyneuropathy; Oligonucleotide; RNA; Dorsum; MALAT1; DNA; Gene silencing; Biology; Cell biology; Molecular biology; Long non-coding RNA; Genetics; Anatomy; Medicine; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169886,0.0002269414,0.0001415815,0.0001258581,0.00009905379,0.000169899,0.0001088332,0.0002356954,0.0005968997],"category_scores_gemma":[0.00007260265,0.0000799958,0.0001496027,0.00006497957,0.0001990187,0.0001347394,0.0001021383,0.0003067489,0.00009980328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011311,"about_ca_system_score_gemma":0.0001148665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003216324,"about_ca_topic_score_gemma":0.0004698542,"domain_scores_codex":[0.9999237,0.00001040472,0.000007468266,0.00002891343,0.0000158189,0.00001359995],"domain_scores_gemma":[0.9999332,0.00001420719,0.00002427454,0.000005954533,0.000006258146,0.00001591597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004798544,0.000005983797,0.00009997706,0.00001622824,0.000001822622,0.00001986554,0.000005069836,0.00001718717,0.9993553,0.00002208308,0.000002590007,0.0004059255],"study_design_scores_gemma":[0.000009840154,0.0004572259,0.005598774,0.000005254322,0.00001912079,0.000192187,0.00002625904,0.0004826514,0.9926944,0.00004118487,0.0004705403,0.000002477655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960533,0.001753683,0.001629514,0.0000579942,0.00001736648,0.00001143397,0.00007873779,0.00002174846,0.0003761538],"genre_scores_gemma":[0.9971548,0.0007780842,0.001079132,0.00003476326,0.000004674218,0.00001198897,0.00008917134,0.000005434348,0.0008419569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005968997,"threshold_uncertainty_score":0.001996875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00446127956536861,"score_gpt":0.2356997822019458,"score_spread":0.2312385026365772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}