{"id":"W4220755703","doi":"10.1126/scitranslmed.abl6328","title":"A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases","year":2022,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fonds de Recherche du Québec - Santé; National Institutes of Health; Fondazione Cariplo; Canadian Institutes of Health Research; Compagnia di San Paolo; Fondazione per la Ricerca sulla Fibrosi Cistica; Bundesministerium für Bildung und Forschung; Cystic Fibrosis Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; PI3K/AKT/mTOR pathway; Phosphodiesterase; Protein kinase A; Cyclic adenosine monophosphate; Cell biology; Endocrinology; Phosphoinositide 3-kinase; Phosphorylation; Internal medicine; Chemistry; Cystic fibrosis; Medicine; Biology; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000428685,0.00009534892,0.0001004083,0.0001915507,0.0003342773,0.00001199237,0.0000961888,0.00002151325,0.0001286558],"category_scores_gemma":[0.0001724795,0.0000868783,0.00002160546,0.0004867367,0.0004652672,0.00002781133,0.00002726156,0.00007966627,7.953663e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004748597,"about_ca_system_score_gemma":0.0001969474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002598814,"about_ca_topic_score_gemma":0.000023286,"domain_scores_codex":[0.9987803,0.00006767782,0.0002430397,0.0003244051,0.0004361051,0.0001485433],"domain_scores_gemma":[0.999594,0.00003557553,0.00008939575,0.0001130119,0.00008633641,0.00008163015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002512612,0.00003721659,0.02762339,0.00001763753,0.00001132528,0.000001565436,0.001817636,0.009001076,0.9456586,0.001138685,0.0001999481,0.01424169],"study_design_scores_gemma":[0.002624085,0.0003808712,0.9574608,0.0000424352,0.00002913731,0.0000323799,0.001211895,0.006607023,0.0243687,0.002591105,0.004390827,0.000260803],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952288,0.0005254656,0.0009112034,0.002163738,0.0002540732,0.0002466661,0.00001343342,0.00001127838,0.0006453271],"genre_scores_gemma":[0.9988616,0.00001889369,0.0004298815,0.0001236352,0.0001418911,0.00004211755,0.0001756971,0.000006172922,0.0002001047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9298373,"threshold_uncertainty_score":0.3542794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008261489651523119,"score_gpt":0.253309549596923,"score_spread":0.2450480599453999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}