{"id":"W4220755703","doi":"10.1126/scitranslmed.abl6328","title":"A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases","year":2022,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fonds de Recherche du Québec - Santé; National Institutes of Health; Fondazione Cariplo; Canadian Institutes of Health Research; Compagnia di San Paolo; Fondazione per la Ricerca sulla Fibrosi Cistica; Bundesministerium für Bildung und Forschung; Cystic Fibrosis Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; PI3K/AKT/mTOR pathway; Phosphodiesterase; Protein kinase A; Cyclic adenosine monophosphate; Cell biology; Endocrinology; Phosphoinositide 3-kinase; Phosphorylation; Internal medicine; Chemistry; Cystic fibrosis; Medicine; Biology; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107302,0.0002843132,0.0003007981,0.0001511834,0.000132453,0.000193748,0.0001725252,0.0003503322,0.001086481],"category_scores_gemma":[0.0001182684,0.0001263801,0.0002654894,0.0001084069,0.0002198695,0.0002050114,0.0001787019,0.0009540311,0.0002217555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002207532,"about_ca_system_score_gemma":0.0001772969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002629905,"about_ca_topic_score_gemma":0.000296416,"domain_scores_codex":[0.9999136,0.000009701789,0.00001007805,0.00001763407,0.00002038951,0.00002860942],"domain_scores_gemma":[0.9999657,0.000004310228,0.000008270259,0.000003100224,0.000003457197,0.00001527393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003952907,0.00006585606,0.00009663169,0.0000566224,0.000005039297,0.00006729311,0.000007688366,0.0000373464,0.9974877,0.00007297732,0.0001011427,0.001606527],"study_design_scores_gemma":[0.0001769678,0.001541631,0.01019039,0.00001512026,0.00004511631,0.0006427707,0.00003820323,0.00103218,0.9822448,0.0001676275,0.00389771,0.000007634965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907064,0.005093594,0.001590226,0.0003767603,0.0001408409,0.00004956345,0.0003529682,0.0001242351,0.001565268],"genre_scores_gemma":[0.9957265,0.001623113,0.0009526405,0.0001695458,0.00002369511,0.00005409861,0.0003118033,0.000008834489,0.001129805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086481,"threshold_uncertainty_score":0.003634632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008261489651523119,"score_gpt":0.253309549596923,"score_spread":0.2450480599453999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}