{"id":"W4220757320","doi":"10.3390/biology11040504","title":"Myc-Interacting Zinc Finger Protein 1 (Miz-1) Is Essential to Maintain Homeostasis and Immunocompetence of the B Cell Lineage","year":2022,"lang":"en","type":"article","venue":"Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Immunosenescence; Biology; Immunocompetence; Immune system; Bone marrow; Haematopoiesis; Immunology; B cell; Cell biology; Zinc finger; Immunodeficiency; Transcription factor; Homeostasis; Lymphopoiesis; Acquired immune system; Stem cell; Genetics; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326629,0.0003373568,0.000229035,0.000283849,0.0003155278,0.0003731839,0.0002984526,0.0003143444,0.0008344006],"category_scores_gemma":[0.000181374,0.0001151359,0.0001712902,0.0002074867,0.0003516263,0.000221264,0.0003549087,0.0003840601,0.0005013341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538583,"about_ca_system_score_gemma":0.0002021003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002863338,"about_ca_topic_score_gemma":0.0002961205,"domain_scores_codex":[0.9998605,0.00001978977,0.00001275262,0.00003755886,0.00003713492,0.0000321363],"domain_scores_gemma":[0.9997833,0.00001793179,0.0001091893,0.00001264937,0.00001597264,0.00006100953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001703911,0.00001621571,0.00107558,0.0001049007,0.000008353457,0.0001621145,0.00002044548,0.00009218923,0.9918961,0.000431701,0.0002042838,0.005817649],"study_design_scores_gemma":[0.00003899107,0.0004212723,0.02604467,0.00002528422,0.0000594561,0.002711704,0.00008818498,0.001590701,0.932019,0.0004215894,0.03656157,0.00001761402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583278,0.02224827,0.01410057,0.0003983694,0.0001678683,0.00003957243,0.001814668,0.0005453551,0.002357551],"genre_scores_gemma":[0.9905365,0.002996206,0.003022779,0.00007275539,0.00003751711,0.00002147088,0.0008044153,0.00003051493,0.002477723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008344006,"threshold_uncertainty_score":0.002791345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008070290676058613,"score_gpt":0.2238568246680068,"score_spread":0.2157865339919482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}