{"id":"W4220757320","doi":"10.3390/biology11040504","title":"Myc-Interacting Zinc Finger Protein 1 (Miz-1) Is Essential to Maintain Homeostasis and Immunocompetence of the B Cell Lineage","year":2022,"lang":"en","type":"article","venue":"Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Immunosenescence; Biology; Immunocompetence; Immune system; Bone marrow; Haematopoiesis; Immunology; B cell; Cell biology; Zinc finger; Immunodeficiency; Transcription factor; Homeostasis; Lymphopoiesis; Acquired immune system; Stem cell; Genetics; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000385412,0.0002247443,0.0003967618,0.00013178,0.0005309379,0.000009356228,0.0006103714,0.0002006243,0.001994796],"category_scores_gemma":[0.00008637429,0.000173237,0.0001388624,0.000233772,0.0004043403,0.00003490438,0.001363973,0.000610148,0.0001139454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004705882,"about_ca_system_score_gemma":0.0000799496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005036091,"about_ca_topic_score_gemma":0.0000226608,"domain_scores_codex":[0.9978395,0.0007184939,0.0004446126,0.0004666024,0.00003436608,0.0004964189],"domain_scores_gemma":[0.9989151,0.0002432639,0.0002834099,0.0004811552,0.00005577041,0.00002124746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002661659,0.000177522,0.0008887522,0.00001849241,0.00009418219,0.000003784436,0.0008064542,0.00000431888,0.9937429,0.0008439776,0.0008427989,0.002310634],"study_design_scores_gemma":[0.000911608,0.0005613662,0.0005204788,0.00001664477,0.00003015252,0.00009613514,0.0009462785,0.000005560947,0.8831218,0.0001416937,0.1134419,0.0002063296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924794,0.003667722,0.0001046483,0.001328116,0.001247917,0.0005531233,0.000137393,0.00003763778,0.0004440146],"genre_scores_gemma":[0.9959655,0.00004746718,0.0002624736,0.000622133,0.0000364359,0.000121862,0.00004213766,0.00001996216,0.002881987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1125991,"threshold_uncertainty_score":0.9989175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008070290676058613,"score_gpt":0.2238568246680068,"score_spread":0.2157865339919482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}