{"id":"W4220758097","doi":"10.1139/cjc-2021-0359","title":"Allosteric regulation of cyclic nucleotide-dependent protein kinases","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Chemistry; Effector; Allosteric enzyme; Kinase; Small molecule; Computational biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196144,0.00009142029,0.0001236364,0.00003712497,0.00008345681,0.00001184788,0.0003105506,0.00005148014,0.0005959484],"category_scores_gemma":[0.0001587193,0.0001046759,0.0001119635,0.00007849269,0.00006761838,0.000003578469,0.00004321979,0.0001318427,8.100444e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008242001,"about_ca_system_score_gemma":0.001025151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001907858,"about_ca_topic_score_gemma":0.00009257963,"domain_scores_codex":[0.99918,0.00004268403,0.0002976213,0.0001242595,0.0001931844,0.0001622479],"domain_scores_gemma":[0.9990502,0.000005476885,0.0003093639,0.0002283729,0.0001221389,0.0002844438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000531761,0.00002281507,0.001746207,0.00003698217,0.00003582532,0.00005111973,0.00003845401,0.0006579081,0.9952142,0.000002929803,0.001855627,0.0002848199],"study_design_scores_gemma":[0.000345357,0.0001076802,0.0008043766,0.00002775105,0.00001729686,0.000156704,0.0001620978,0.000004890299,0.9908458,0.0001032038,0.007317251,0.0001076009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979842,0.000790216,0.00002779217,0.000125999,0.0001013654,0.0000672592,0.00008312391,0.000001863626,0.000818201],"genre_scores_gemma":[0.9989603,0.000002316481,0.00009234512,0.00006960307,0.0001656824,0.000006776942,0.0000400786,0.00001879063,0.000644095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005461624,"threshold_uncertainty_score":0.6525217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00835412518148884,"score_gpt":0.203744299843578,"score_spread":0.1953901746620891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}