{"id":"W4220759987","doi":"10.1101/2022.03.23.485469","title":"CD4 binding-site antibodies induced by a subtype B HIV-1 envelope trimer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Rijksinstituut voor Volksgezondheid en Milieu; Bill and Melinda Gates Foundation; European Commission; Amsterdam University Medical Centers; amfAR, The Foundation for AIDS Research; National Institutes of Health; Universiteit van Amsterdam; International AIDS Vaccine Initiative","keywords":"Trimer; Neutralization; Heterologous; Antibody; Virology; Polyclonal antibodies; Epitope; HIV vaccine; Avidity; Glycoprotein; Neutralizing antibody; Binding site; Biology; Immunogen; Chemistry; Immunology; Molecular biology; Monoclonal antibody; Vaccine trial; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990457,0.0002327439,0.0001712848,0.0001873692,0.000151301,0.0001907917,0.0001280479,0.0004049866,0.001597583],"category_scores_gemma":[0.0001481866,0.0001108515,0.0002287722,0.00006193575,0.00015517,0.0001133661,0.0001983178,0.0006265861,0.0003636835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033126,"about_ca_system_score_gemma":0.0001101785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000593227,"about_ca_topic_score_gemma":0.0003786554,"domain_scores_codex":[0.9998559,0.00003129559,0.000007465295,0.00002259953,0.00003211526,0.00005065949],"domain_scores_gemma":[0.9999236,0.00002154141,0.00001234012,0.00001267484,0.00001124413,0.00001863148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001282466,0.00004246887,0.0004543924,0.00001460517,0.000004633474,0.00008821484,0.00001007066,0.00004599356,0.9983268,0.00004171328,0.00005673525,0.0007861198],"study_design_scores_gemma":[0.00004988445,0.00163847,0.01473891,0.000007843762,0.00002475361,0.000937784,0.00004724172,0.002116259,0.9784095,0.0001584291,0.001867377,0.000003495751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962447,0.0002631969,0.001007889,0.00006132688,0.00001981608,0.00002939893,0.0000566824,0.00004554103,0.002271259],"genre_scores_gemma":[0.9972806,0.00008289141,0.0009463941,0.0001737279,0.00001077124,0.00001140748,0.00009964095,0.000009906861,0.001384516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597583,"threshold_uncertainty_score":0.00534445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0192220917137929,"score_gpt":0.2469127462734044,"score_spread":0.2276906545596115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}