{"id":"W4220765749","doi":"10.7554/elife.74509.sa2","title":"Author response: Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription","year":2022,"lang":"en","type":"peer-review","venue":"","topic":"Insect behavior and control techniques","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Transcription factor; Biology; Transcription (linguistics); Computational biology; Genetics; Cell biology; Gene; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001785735,0.0002092554,0.0004687435,0.00002776403,0.0001320352,0.00002000491,0.0006821898,0.0001888366,0.001053712],"category_scores_gemma":[0.00010447,0.0000547095,0.0002811815,0.0004330382,0.0002660942,0.00005526243,0.00008631729,0.0004311465,4.664931e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003726698,"about_ca_system_score_gemma":0.00002915275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000635403,"about_ca_topic_score_gemma":0.002574541,"domain_scores_codex":[0.9974909,0.001012107,0.0006167646,0.000257573,0.0004589847,0.0001636869],"domain_scores_gemma":[0.9988354,0.0003438953,0.0004436748,0.0002111323,0.0001505944,0.00001530927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006336325,0.0003631703,0.000983063,0.0008978919,0.00006062989,0.000001249406,0.001116059,8.076749e-7,0.3918462,0.004669318,0.01104906,0.588379],"study_design_scores_gemma":[0.0006646686,0.00334783,0.2161148,0.006170113,0.001243892,0.0002838524,0.01344544,0.0003428299,0.05586382,0.008458682,0.6928123,0.00125179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9259269,0.01111783,0.000001219281,0.05654331,0.0004881275,0.002619706,0.000831149,0.0000303236,0.002441386],"genre_scores_gemma":[0.9855872,0.002849493,0.00001778186,0.0001863908,0.00005834991,0.0001542957,0.00006057619,0.000002985443,0.01108289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6817632,"threshold_uncertainty_score":0.9998595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03022043602453346,"score_gpt":0.2564943434098427,"score_spread":0.2262739073853092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}