{"id":"W4220768918","doi":"10.1101/2022.03.30.486377","title":"ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Helmut Horten Stiftung; Eidgenössische Technische Hochschule Zürich; University of Washington; Fast Grants; Institute for Research in Biomedicine; Burroughs Wellcome Fund; Howard Hughes Medical Institute","keywords":"Monoclonal antibody; Virology; Epitope; Glycoprotein; Coronavirus; Biology; Antibody; Lipid bilayer fusion; Peptide; Neutralizing antibody; Viral entry; Fusion protein; Molecular biology; Virus; Coronavirus disease 2019 (COVID-19); Gene; Genetics; Biochemistry; Recombinant DNA; Medicine; Viral replication; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119442,0.0002266074,0.0001423211,0.00008693138,0.00009974714,0.0002213594,0.0001143332,0.0002322584,0.002066499],"category_scores_gemma":[0.00009723809,0.00006972387,0.000143405,0.00006116789,0.00009016579,0.0001203986,0.0001422482,0.0003501617,0.0004286939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215202,"about_ca_system_score_gemma":0.0001086904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003925006,"about_ca_topic_score_gemma":0.0004779003,"domain_scores_codex":[0.9999207,0.00001122109,0.000003162552,0.00001381155,0.00001667351,0.00003431521],"domain_scores_gemma":[0.9999596,0.000009898465,0.000005713188,0.000005468944,0.000006915654,0.00001244222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009257025,0.00002147886,0.0001916595,0.000009070625,0.000004054136,0.00004953067,0.000007394346,0.00006566649,0.9985883,0.00008657105,0.00008260352,0.0008011303],"study_design_scores_gemma":[0.00001717861,0.0001814692,0.002933643,0.000002340317,0.000005767295,0.000327489,0.00001502111,0.001355254,0.9927048,0.00004242339,0.002412467,0.000002075327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932351,0.000523594,0.002241965,0.00008906866,0.0000234183,0.0000140984,0.0001415956,0.00004464947,0.003686426],"genre_scores_gemma":[0.9960265,0.0001744715,0.0008215549,0.0001045778,0.00001216032,0.000009459384,0.000258351,0.000009391912,0.002583591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002066499,"threshold_uncertainty_score":0.006913126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06772563177354944,"score_gpt":0.3328472435571139,"score_spread":0.2651216117835645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}