{"id":"W4220771233","doi":"10.1101/2022.03.23.485329","title":"Fate and state transitions during human blood vessel organoid development","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Innovative Medicines Initiative; Canadian Institutes of Health Research; Eidgenössische Technische Hochschule Zürich; Austrian Science Fund; Österreichischen Akademie der Wissenschaften; Chan Zuckerberg Initiative; Silicon Valley Community Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Mural cell; Cell fate determination; Cell biology; Progenitor cell; Transcriptome; Induced pluripotent stem cell; Notch signaling pathway; Fate mapping; Stem cell; Vasculogenesis; Endothelial stem cell; Cellular differentiation; Transcription factor; Transplantation; Directed differentiation; Reprogramming; Cell type; Cell; Genetics; Signal transduction; Gene; Gene expression; In vitro; Embryonic stem cell; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008089679,0.00006459726,0.0001016631,0.0001589951,0.0001134328,0.0003225715,0.0000905241,0.0001271623,0.0006856286],"category_scores_gemma":[0.0001451802,0.00009954123,0.0001008062,0.0001148968,0.0001137419,0.0001462995,0.000160969,0.000156528,0.0002043169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002067307,"about_ca_system_score_gemma":0.0001181237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011312,"about_ca_topic_score_gemma":0.001502713,"domain_scores_codex":[0.9999355,0.000006125889,0.000003259168,0.0000231537,0.00001996698,0.0000119805],"domain_scores_gemma":[0.9999433,0.00001634331,0.00001563543,0.000006606916,0.000008089476,0.00001007773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004444509,0.000003371674,0.00156446,0.00000991148,0.000002124565,0.00003907808,0.00005978071,0.0002334865,0.9954019,0.000156795,0.00003009569,0.002454524],"study_design_scores_gemma":[0.000004589057,0.00007114938,0.03967246,0.000007811478,0.00001088344,0.0002308791,0.0001538384,0.003372155,0.9522285,0.0002730053,0.003963452,0.00001115801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909486,0.0005739405,0.006336133,0.0000220679,0.000005562813,0.00001201011,0.0005909179,0.00007053154,0.001440234],"genre_scores_gemma":[0.9945197,0.0003582351,0.002557239,0.00002195874,0.000001613362,0.00002357483,0.0007873992,0.00002277753,0.001707594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0011312,"threshold_uncertainty_score":0.002293646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100148284894136,"score_gpt":0.2017827824671989,"score_spread":0.1917679539777853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}