{"id":"W4220771233","doi":"10.1101/2022.03.23.485329","title":"Fate and state transitions during human blood vessel organoid development","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Innovative Medicines Initiative; Canadian Institutes of Health Research; Eidgenössische Technische Hochschule Zürich; Austrian Science Fund; Österreichischen Akademie der Wissenschaften; Chan Zuckerberg Initiative; Silicon Valley Community Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Mural cell; Cell fate determination; Cell biology; Progenitor cell; Transcriptome; Induced pluripotent stem cell; Notch signaling pathway; Fate mapping; Stem cell; Vasculogenesis; Endothelial stem cell; Cellular differentiation; Transcription factor; Transplantation; Directed differentiation; Reprogramming; Cell type; Cell; Genetics; Signal transduction; Gene; Gene expression; In vitro; Embryonic stem cell; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002427191,0.0004907757,0.0003676444,0.0001419191,0.000554535,0.0001378871,0.0003797586,0.0003087359,0.00005660137],"category_scores_gemma":[0.00001966053,0.0005909758,0.0001074093,0.0001588548,0.0001093264,0.00000805714,0.0004299739,0.0005368299,0.000004459075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006830318,"about_ca_system_score_gemma":0.0003901491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000264232,"about_ca_topic_score_gemma":0.00001070511,"domain_scores_codex":[0.9977313,0.00009778553,0.0004636444,0.000993113,0.0002393718,0.0004747468],"domain_scores_gemma":[0.9987285,0.000005714454,0.0001834696,0.0007058425,0.0001528361,0.0002236284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003403423,0.0002023722,0.004493188,0.0003304965,0.0002624319,0.00004008216,0.00004504259,0.00008460874,0.9944571,0.00002245185,0.00002696777,0.000001249252],"study_design_scores_gemma":[0.000882601,0.00007776998,0.05132819,0.00007947532,0.0001107263,8.642427e-8,0.000005481968,0.000008061575,0.9417052,0.000001092733,0.005061989,0.0007392663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969602,0.001148581,0.0006369603,0.00006096454,0.0003878273,0.0004160345,0.0002639616,0.0001151371,0.00001028207],"genre_scores_gemma":[0.9966062,0.0004521605,0.002281107,0.0001039328,0.0002060727,0.0001659068,0.000008072773,0.0001415825,0.00003501274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05275182,"threshold_uncertainty_score":0.9996542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100148284894136,"score_gpt":0.2017827824671989,"score_spread":0.1917679539777853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}