{"id":"W4220776360","doi":"10.1038/s41568-022-00454-5","title":"Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer","year":2022,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":356,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute","keywords":"Cancer cell; Cancer; Exploit; Immune system; Biology; DNA damage; Tumor microenvironment; Cancer research; Medicine; Bioinformatics; Immunology; Computer science; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001253282,0.0009145244,0.001543748,0.001543202,0.0002962578,0.001439272,0.001614129,0.002057755,0.003885336],"category_scores_gemma":[0.001323315,0.0003018009,0.0004470652,0.001827525,0.001208466,0.001857536,0.001197451,0.003648607,0.002094917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001212986,"about_ca_system_score_gemma":0.001044661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008395523,"about_ca_topic_score_gemma":0.002290708,"domain_scores_codex":[0.9997004,0.00006757514,0.00002648553,0.00004219056,0.000123909,0.00003945858],"domain_scores_gemma":[0.9992945,0.0003815685,0.00005949557,0.00002457741,0.0001518824,0.00008794688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001000756,0.00003826513,0.0001267721,0.007365559,0.00008278757,0.0002359762,0.00004912247,0.0006362216,0.002066579,0.01238515,0.0956711,0.8812424],"study_design_scores_gemma":[0.00001851092,0.00004455189,0.0003850179,0.001481629,0.00005015629,0.0009450053,0.00003412051,0.00009990963,0.0003588118,0.004329049,0.992239,0.0000142966],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004460811,0.9977438,0.0001747908,0.0009490169,0.0004113374,0.000001906478,0.00001064248,0.000008001616,0.0006559388],"genre_scores_gemma":[0.0005233694,0.9978703,0.0001144729,0.0005420503,0.0004138013,0.000003950716,0.00001932616,0.000002064205,0.0005106145],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003885336,"threshold_uncertainty_score":0.01299775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1217274315667971,"score_gpt":0.4069908961631901,"score_spread":0.285263464596393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}