{"id":"W4220781691","doi":"10.1111/bdi.13205","title":"The role of bipolar polygenic risk score in the familial transmission of bipolar disorder—An updated analysis","year":2022,"lang":"en","type":"article","venue":"Bipolar Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Saint John Regional Hospital; Dalhousie University","funders":"National Institute of Mental Health","keywords":"Polygenic risk score; Bipolar disorder; Psychology; Clinical psychology; Psychiatry; Medicine; Genetics; Biology; Mood; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001234818,0.0004296677,0.0007501605,0.0007073242,0.0008441223,0.00002570035,0.0008414008,0.0001489848,0.0003337137],"category_scores_gemma":[0.0000536916,0.0002768186,0.00081174,0.003459605,0.0003570195,0.000136294,0.0001438726,0.0007832204,0.000004966157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008993316,"about_ca_system_score_gemma":0.000253217,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01447107,"about_ca_topic_score_gemma":0.01537855,"domain_scores_codex":[0.9956317,0.001110012,0.00091272,0.0005952679,0.001121738,0.0006285597],"domain_scores_gemma":[0.9978422,0.0001992108,0.0004223532,0.001288726,0.00008518886,0.0001623507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004791415,0.001687898,0.672361,0.00002282209,0.001041209,0.000001569917,0.002749029,0.0003424047,0.001534748,0.0003168241,0.00002139984,0.319442],"study_design_scores_gemma":[0.002403836,0.001074153,0.5406144,0.00001079041,0.002526033,0.000008405533,0.00732518,0.00304532,0.0004690458,0.0006212286,0.4416334,0.0002682179],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6359219,0.3615747,0.0003040195,0.0005298395,0.00007438298,0.001077219,0.0003624565,0.00004792827,0.0001076122],"genre_scores_gemma":[0.962575,0.03638446,0.00009815327,0.00005675592,0.00002345397,0.0001231149,0.0006170525,0.000061121,0.00006095075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.441612,"threshold_uncertainty_score":0.9999684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006699893929716132,"score_gpt":0.2350612541892949,"score_spread":0.2283613602595788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}