{"id":"W4220782725","doi":"10.1139/bcb-2021-0540","title":"The biological relevance of PCSK9: when less is better…","year":2022,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Fondation Jean-Louis Lévesque","keywords":"PCSK9; Kexin; Proprotein convertase; LDL receptor; Biology; Immunity; Cholesterol; Inflammation; Regulator; Immunology; Lipoprotein; Endocrinology; Internal medicine; Medicine; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002683331,0.0004641473,0.0006249127,0.0008182462,0.0001804243,0.0009089005,0.0003912025,0.000746751,0.003051577],"category_scores_gemma":[0.000477952,0.0001112596,0.0003220939,0.0007625362,0.0003500234,0.0009144171,0.0004576419,0.001419017,0.001643045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000366176,"about_ca_system_score_gemma":0.000505934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005128859,"about_ca_topic_score_gemma":0.0007660022,"domain_scores_codex":[0.9998628,0.00002366354,0.0000198107,0.00002699823,0.00005190713,0.00001490442],"domain_scores_gemma":[0.9998904,0.00004761286,0.00001628165,0.000003745459,0.00003069313,0.00001112536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001252862,0.00003412421,0.0002584131,0.01399297,0.0001072591,0.0002317693,0.0001006703,0.0001665191,0.005266793,0.007142248,0.03271553,0.9398584],"study_design_scores_gemma":[0.00001407162,0.00007539632,0.0008633381,0.001873257,0.00008332403,0.00149612,0.00005872085,0.00004503563,0.001062917,0.002295304,0.9921197,0.00001284929],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000392895,0.9959669,0.0002325809,0.001015862,0.0005117535,0.000003298149,0.00003763583,0.00001023837,0.001828836],"genre_scores_gemma":[0.002350472,0.9946854,0.0002312882,0.0006051484,0.0002894836,0.000005119476,0.00006452018,0.000003259034,0.001765247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003051577,"threshold_uncertainty_score":0.01020855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04882303932400325,"score_gpt":0.3009477059231311,"score_spread":0.2521246665991279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}