{"id":"W4220783087","doi":"10.1083/jcb.202104022","title":"GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression","year":2021,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Guangzhou Municipal Science and Technology Project; European Research Council; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ministry of Science and ICT, South Korea; Ministry of Science ICT and Future Planning; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Foundation of Korea; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China; École Polytechnique Fédérale de Lausanne","keywords":"Acetylation; Zinc finger; YY1; Biology; Cell biology; P300-CBP Transcription Factors; Transcription factor; Lysine; Biochemistry; Chemistry; Gene expression; Histone Acetyltransferases; Gene; Amino acid; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429267,0.0002212811,0.00016586,0.0001650742,0.0001531446,0.0001725126,0.0002306391,0.0001689186,0.0008415515],"category_scores_gemma":[0.00009177956,0.00007797313,0.0001692516,0.0001006889,0.0001831957,0.0001458919,0.0002502507,0.0002060638,0.0002022937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004398721,"about_ca_system_score_gemma":0.0002599687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001714238,"about_ca_topic_score_gemma":0.005281785,"domain_scores_codex":[0.9999156,0.000012353,0.000008222009,0.00002380075,0.00002177021,0.00001819023],"domain_scores_gemma":[0.9999459,0.000004715593,0.00001734969,0.000005747187,0.000006749353,0.00001950524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003766152,0.000003247383,0.000417608,0.0000267144,0.00000382307,0.00002907519,0.000006748638,0.00004312989,0.9982868,0.00007933028,0.00003034775,0.001035546],"study_design_scores_gemma":[0.00000950895,0.0001179445,0.0150128,0.00001147069,0.00001619373,0.0002248059,0.00002779443,0.001187508,0.9788028,0.00008338214,0.004501277,0.00000457183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883145,0.004753839,0.004957862,0.0001431779,0.00004886132,0.00001471028,0.0002828161,0.00008631303,0.001397848],"genre_scores_gemma":[0.9940516,0.0009261898,0.002831838,0.00004927862,0.000006433635,0.000009793435,0.0002766703,0.00001415699,0.001834037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714238,"threshold_uncertainty_score":0.003408492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008449458126691897,"score_gpt":0.255579361364525,"score_spread":0.2471299032378331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}