{"id":"W4220783948","doi":"10.1158/1078-0432.ccr-21-3089","title":"Putative Biomarkers of Clinical Benefit With Pembrolizumab in Advanced Urothelial Cancer: Results from the KEYNOTE-045 and KEYNOTE-052 Landmark Trials","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Pembrolizumab; Clinical trial; Tumor microenvironment; Urothelial cancer; Biomarker; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006099244,0.0009446298,0.001598017,0.0002698761,0.0002340273,0.001457566,0.0006365963,0.0007948304,0.001477297],"category_scores_gemma":[0.005031929,0.0002275116,0.002533774,0.0005496324,0.0005418058,0.001162976,0.0005570087,0.001775262,0.0002239184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008473994,"about_ca_system_score_gemma":0.0009591011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004214712,"about_ca_topic_score_gemma":0.001355245,"domain_scores_codex":[0.9981364,0.00113291,0.0001366154,0.0002693405,0.0001958334,0.0001288623],"domain_scores_gemma":[0.9961482,0.00125287,0.001660624,0.0002848738,0.0002374188,0.0004161114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7086227,0.002753613,0.08428189,0.005272508,0.02064051,0.0001460169,0.0002162064,0.003475087,0.00832474,0.0007304267,0.004536945,0.1609995],"study_design_scores_gemma":[0.2815008,0.1966823,0.4521101,0.001599235,0.03530037,0.000769006,0.000341397,0.004666663,0.00559665,0.002003951,0.01923493,0.0001945374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.942171,0.05011973,0.0008979798,0.00144757,0.0001592819,0.0005297404,0.002506881,0.00006188148,0.002106052],"genre_scores_gemma":[0.99138,0.004161455,0.0008612103,0.0006869649,0.0001774119,0.0003073585,0.001954843,0.00001087898,0.0004598947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006099244,"threshold_uncertainty_score":0.03225625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3133351769610583,"score_gpt":0.554651027683863,"score_spread":0.2413158507228046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}