{"id":"W4220783948","doi":"10.1158/1078-0432.ccr-21-3089","title":"Putative Biomarkers of Clinical Benefit With Pembrolizumab in Advanced Urothelial Cancer: Results from the KEYNOTE-045 and KEYNOTE-052 Landmark Trials","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Pembrolizumab; Clinical trial; Tumor microenvironment; Urothelial cancer; Biomarker; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01299119,0.0003246768,0.00186416,0.0001851818,0.000334324,0.00003659366,0.0005097459,0.000218533,0.0008000374],"category_scores_gemma":[0.00549293,0.0002020188,0.0003702713,0.0009801371,0.001219693,0.00009868771,0.0004500877,0.002108569,0.000007200068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000382411,"about_ca_system_score_gemma":0.002604404,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02525729,"about_ca_topic_score_gemma":0.004819198,"domain_scores_codex":[0.9900837,0.003740251,0.002613589,0.00125067,0.001576148,0.0007356511],"domain_scores_gemma":[0.9821307,0.01547772,0.000641456,0.0008578802,0.0004678369,0.00042438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.273291,0.001082107,0.5138655,0.000065062,0.001338222,0.0001837414,0.001356681,0.0002584303,0.0001554307,0.00006077211,0.002738122,0.2056049],"study_design_scores_gemma":[0.08885782,0.008286047,0.8819689,0.0004914041,0.00047284,0.00001171163,0.001765552,0.0003951208,0.0005752849,0.0016022,0.01519697,0.0003761069],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776546,0.005522825,0.00001091462,0.008459273,0.0006329064,0.002530208,0.004065483,0.00003047044,0.001093315],"genre_scores_gemma":[0.9893255,0.006928472,0.0002034936,0.0008036032,0.0008966378,0.00103877,0.0001172209,0.00006781003,0.0006185195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3681034,"threshold_uncertainty_score":0.9812336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3133351769610583,"score_gpt":0.554651027683863,"score_spread":0.2413158507228046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}