{"id":"W4220784793","doi":"10.1016/bs.vh.2022.01.010","title":"Inherited defects of cobalamin metabolism","year":2022,"lang":"en","type":"article","venue":"Vitamins and hormones","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Cobalamin; Homocystinuria; Methionine synthase; Adenosylcobalamin; Methylcobalamin; Methylmalonic acidemia; Methylmalonic acid; Mutase; Methylmalonic aciduria; Homocysteine; Biochemistry; Vitamin B12; Cystathionine beta synthase; Chemistry; Cofactor; Methionine; Biology; Enzyme; Endocrinology; Cysteine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887709,0.00009776467,0.0002727496,0.0001992363,0.00013813,0.000009777416,0.00006824436,0.0000361282,0.0001707261],"category_scores_gemma":[0.0000415925,0.00008206639,0.00006666541,0.000367908,0.00009065196,0.00004718025,0.0001701833,0.0001704556,0.00000518843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001735017,"about_ca_system_score_gemma":0.00006300877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001476792,"about_ca_topic_score_gemma":0.00001332045,"domain_scores_codex":[0.9990828,0.00004643128,0.0001716857,0.0001775859,0.000320312,0.0002011787],"domain_scores_gemma":[0.9995628,0.00005364079,0.00004233246,0.0001856624,0.00005890791,0.00009663947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006232507,0.0009313398,0.04388117,0.0003307927,0.0002812441,0.0002457327,0.00158521,0.000004366038,0.8985828,0.004077144,0.006137954,0.04331904],"study_design_scores_gemma":[0.002571594,0.001487182,0.9083678,0.00002166282,0.0001562661,0.0002038224,0.001491498,0.000310387,0.01748293,0.0001575891,0.06754892,0.0002003214],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991391,0.005212632,0.000008016689,0.0002551569,0.00005428426,0.0002105234,0.00003639504,0.00002559798,0.002806372],"genre_scores_gemma":[0.9972104,0.0007093621,0.0001334282,0.000122083,0.00004270463,0.00003211489,0.00002908069,0.00001598735,0.00170477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8810998,"threshold_uncertainty_score":0.334657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386880144946099,"score_gpt":0.2602771254427318,"score_spread":0.2464083239932708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}