{"id":"W4220784793","doi":"10.1016/bs.vh.2022.01.010","title":"Inherited defects of cobalamin metabolism","year":2022,"lang":"en","type":"article","venue":"Vitamins and hormones","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Cobalamin; Homocystinuria; Methionine synthase; Adenosylcobalamin; Methylcobalamin; Methylmalonic acidemia; Methylmalonic acid; Mutase; Methylmalonic aciduria; Homocysteine; Biochemistry; Vitamin B12; Cystathionine beta synthase; Chemistry; Cofactor; Methionine; Biology; Enzyme; Endocrinology; Cysteine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003115239,0.002225718,0.0009587813,0.002302455,0.0009035062,0.0007940885,0.001074936,0.001432854,0.01431026],"category_scores_gemma":[0.002069006,0.0003844986,0.0006288532,0.001477122,0.001830231,0.0007278832,0.0009849173,0.001166932,0.001219905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009039677,"about_ca_system_score_gemma":0.0009719742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003974359,"about_ca_topic_score_gemma":0.00214167,"domain_scores_codex":[0.9993868,0.00007094434,0.00008555285,0.0001303431,0.0001839054,0.0001424446],"domain_scores_gemma":[0.9986411,0.0004437985,0.0003806953,0.0001119708,0.0001895839,0.0002328471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003824712,0.000433544,0.1188502,0.0008118055,0.001045748,0.5835966,0.001462595,0.001012885,0.1767864,0.02353908,0.007210645,0.08142582],"study_design_scores_gemma":[0.000397198,0.0008009854,0.119056,0.0003602728,0.001716322,0.7063343,0.0009278865,0.001399109,0.1307924,0.00661594,0.03148779,0.0001119202],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9255509,0.0152688,0.006375128,0.002887777,0.0007607211,0.00006445537,0.002736387,0.0006217512,0.04573395],"genre_scores_gemma":[0.9843147,0.002594071,0.002617531,0.0002598257,0.0003136772,0.00001483343,0.0003854126,0.00007813661,0.009421772],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01431026,"threshold_uncertainty_score":0.0478726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386880144946099,"score_gpt":0.2602771254427318,"score_spread":0.2464083239932708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}