{"id":"W4220787039","doi":"10.1002/prot.26340","title":"Antibody mutations favoring <scp>pH</scp>‐dependent binding in solid tumor microenvironments: Insights from large‐scale structure‐based calculations","year":2022,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Antibody; Chemistry; Cytotoxicity; Biophysics; Complementarity determining region; Binding site; Computational biology; Antigen; Cancer research; Biochemistry; Combinatorial chemistry; Peptide sequence; In vitro; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004647206,0.0005110401,0.0005183188,0.0005123517,0.0004300741,0.0003949772,0.0007998515,0.000644989,0.002080018],"category_scores_gemma":[0.0005309165,0.0002796814,0.0004499077,0.0003141815,0.0004536726,0.0005728738,0.0003118523,0.0006131717,0.0001970574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007922201,"about_ca_system_score_gemma":0.0006995741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004033625,"about_ca_topic_score_gemma":0.006277549,"domain_scores_codex":[0.9998565,0.00003023282,0.000004605426,0.00001473312,0.00005718183,0.00003668303],"domain_scores_gemma":[0.9997935,0.0001160257,0.00002560771,0.0000144695,0.00003153929,0.00001880843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002536543,0.0003420422,0.004044205,0.0004756426,0.00008931733,0.0006251449,0.0001374216,0.9047066,0.05334229,0.02160642,0.002439657,0.01193749],"study_design_scores_gemma":[0.00005659737,0.00008927032,0.001233309,0.00001200869,0.00002297357,0.00003488529,0.00004066665,0.9898548,0.00430293,0.00378036,0.0005610088,0.00001111211],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519345,0.001040076,0.02809577,0.0005655507,0.00003751974,0.00007980203,0.0003572291,0.0002510578,0.01763837],"genre_scores_gemma":[0.9927163,0.000547611,0.005922571,0.00008394483,0.00001145595,0.00005984695,0.0001927003,0.00005049894,0.0004150887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004033625,"threshold_uncertainty_score":0.008020282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120313770342373,"score_gpt":0.2631646097488887,"score_spread":0.251961472045465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}