{"id":"W4220787039","doi":"10.1002/prot.26340","title":"Antibody mutations favoring <scp>pH</scp>‐dependent binding in solid tumor microenvironments: Insights from large‐scale structure‐based calculations","year":2022,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Antibody; Chemistry; Cytotoxicity; Biophysics; Complementarity determining region; Binding site; Computational biology; Antigen; Cancer research; Biochemistry; Combinatorial chemistry; Peptide sequence; In vitro; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009773939,0.000265004,0.0003303119,0.0004581778,0.0007554743,0.00008087594,0.0001160001,0.00008925551,0.0004725083],"category_scores_gemma":[0.00006405541,0.0002202928,0.00008391335,0.0004328678,0.00008590447,0.0002359429,0.0002027429,0.0007032113,0.00001285239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938626,"about_ca_system_score_gemma":0.0001209981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001635676,"about_ca_topic_score_gemma":0.0001607223,"domain_scores_codex":[0.9979845,0.00007530011,0.0005525092,0.0002823444,0.000694212,0.0004111088],"domain_scores_gemma":[0.9992259,0.00008515599,0.0001991072,0.0002376324,0.00005388479,0.0001983878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004854428,0.0005748076,0.2603162,0.0007996652,0.0003709392,0.0001109748,0.0105938,0.007279424,0.7151825,0.0005603372,0.0002420246,0.003483889],"study_design_scores_gemma":[0.01187844,0.001651198,0.5940012,0.0003364536,0.0004010379,0.000357074,0.02677247,0.272471,0.05585375,0.004266909,0.03123261,0.0007777891],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907731,0.0001964991,0.005859401,0.0001788451,0.0002694391,0.001026808,0.001301932,0.00005190625,0.0003420168],"genre_scores_gemma":[0.9874665,0.00001614513,0.007782691,0.0005529904,0.0001213009,0.00005080811,0.003703321,0.00002390116,0.0002823862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6593288,"threshold_uncertainty_score":0.8983281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120313770342373,"score_gpt":0.2631646097488887,"score_spread":0.251961472045465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}