{"id":"W4220787128","doi":"10.26508/lsa.202201379","title":"Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Horizon 2020 Framework Programme; Cancéropôle Grand Ouest; Institut National Du Cancer; Vetenskapsrådet; Fondation pour la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; VINNOVA; European Commission","keywords":"XBP1; RNA splicing; Phosphorylation; Cell biology; RNase P; Tyrosine phosphorylation; Biology; Unfolded protein response; Protein tyrosine phosphatase; Alternative splicing; Endoribonuclease; Messenger RNA; Chemistry; Endoplasmic reticulum; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213913,0.0002161664,0.0001861532,0.000108336,0.0001062399,0.0002610054,0.0001310694,0.0001478686,0.001311703],"category_scores_gemma":[0.00009604396,0.00008391438,0.0001835107,0.00009144942,0.0001706297,0.000250073,0.0001756878,0.0003787251,0.0002309546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003040408,"about_ca_system_score_gemma":0.0001706116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003593223,"about_ca_topic_score_gemma":0.0003960995,"domain_scores_codex":[0.9999239,0.000008657155,0.000004027683,0.00002122285,0.00001076516,0.00003138835],"domain_scores_gemma":[0.999953,0.000004263254,0.0000169634,0.00000394869,0.000005897744,0.00001604222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182175,0.000009752092,0.0002948773,0.00001573266,0.000002259575,0.0000311776,0.000006755135,0.00005268735,0.9988601,0.00008024557,0.00001489492,0.0005132616],"study_design_scores_gemma":[0.0000312072,0.000152552,0.02576998,0.000008033857,0.00001601598,0.0002630574,0.00005238513,0.001972565,0.9702858,0.0001539356,0.00128684,0.000007610685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966588,0.001187516,0.001107308,0.00006659793,0.00001243827,0.000008170468,0.0001165449,0.00002065275,0.0008219823],"genre_scores_gemma":[0.9984519,0.0004162958,0.0003041041,0.00001785226,0.000004316045,0.000007687281,0.0001085002,0.000004902264,0.0006844255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001311703,"threshold_uncertainty_score":0.004388034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396509523732989,"score_gpt":0.2578794347378908,"score_spread":0.2439143395005609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}