{"id":"W4220787128","doi":"10.26508/lsa.202201379","title":"Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Horizon 2020 Framework Programme; Cancéropôle Grand Ouest; Institut National Du Cancer; Vetenskapsrådet; Fondation pour la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; VINNOVA; European Commission","keywords":"XBP1; RNA splicing; Phosphorylation; Cell biology; RNase P; Tyrosine phosphorylation; Biology; Unfolded protein response; Protein tyrosine phosphatase; Alternative splicing; Endoribonuclease; Messenger RNA; Chemistry; Endoplasmic reticulum; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943297,0.00008928585,0.00009879799,0.00002461427,0.00024551,0.00002439041,0.0002132446,0.00002451685,0.00001897082],"category_scores_gemma":[0.0001296364,0.00008930268,0.00003157155,0.0002020804,0.0002090368,0.0000150525,0.0002106253,0.00006274187,6.635103e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001335859,"about_ca_system_score_gemma":0.0001479803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004325896,"about_ca_topic_score_gemma":0.000003813647,"domain_scores_codex":[0.9990215,0.00002780299,0.000120599,0.0003630758,0.0002789597,0.0001880605],"domain_scores_gemma":[0.9994686,0.00001091105,0.0001114124,0.000229707,0.00006219142,0.0001171821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004899527,0.00005380383,0.02230357,0.00001543243,0.000005398345,0.000001125516,0.00004507848,0.002536492,0.9734699,0.0001264298,0.00002863442,0.001365135],"study_design_scores_gemma":[0.0002605082,0.0001382435,0.04887293,0.00001213988,0.000007101445,0.000001218284,0.0001039058,0.003149156,0.9471211,0.0000600693,0.0001525532,0.0001211048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982581,0.0009509994,0.0002200696,0.00012648,0.0001115348,0.000105828,0.00004179406,0.000006922037,0.0001782632],"genre_scores_gemma":[0.9993622,0.00008581625,0.0002985327,0.00009813874,0.00003686106,0.00001697029,0.00001124465,0.000006427014,0.00008377014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02656936,"threshold_uncertainty_score":0.3641658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396509523732989,"score_gpt":0.2578794347378908,"score_spread":0.2439143395005609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}