{"id":"W4220787401","doi":"10.1186/s13058-021-01484-x","title":"Common variants in breast cancer risk loci predispose to distinct tumor subtypes","year":2022,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of British Columbia; Simon Fraser University; McGill University; Queen's University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Royal Victoria Hospital; Centre hospitalier universitaire de Québec; St. Francis Xavier University; BC Cancer Agency; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Mailman School of Public Health, Columbia University; National Institute of Environmental Health Sciences; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Canadian Institutes of Health Research; University of California, Irvine; University of North Carolina at Chapel Hill; Weill Cornell Medical College; Pontificia Universidad Javeriana; Pomorski Uniwersytet Medyczny W Szczecinie; Universität zu Köln; Deutsche Kinderkrebsstiftung; Medical Research Council; Uppsala Universitet; University of California, San Diego; Carol M. Baldwin Breast Cancer Research Fund; Johns Hopkins University; Universitetet i Oslo; Odense Universitetshospital; Susan G. Komen for the Cure, Komen Wyoming Affiliate; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Johns Hopkins Bloomberg School of Public Health; University of Edinburgh; Queen's University; National Human Genome Research Institute; Cancer Council Victoria; School of Medicine, Vanderbilt University; St. Francis Xavier University; University of Melbourne; School of Medicine, Stanford University; Institut National de la Santé et de la Recherche Médicale; Kuopion Yliopistollinen Sairaala; Universität Heidelberg; Centro de Investigación Biomédica en Red de Cáncer; Universitätsklinikum Köln; Queen's University Belfast; Lunds Universitet; King's College London; Government of Canada; National Health and Medical Research Council; Oulun Yliopisto; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Deutsche Krebshilfe; University of Toronto; Clalit Health Services; Deutsches Krebsforschungszentrum; Biocenter, University of Oulu; National Institute for Health and Care Research; Eberhard Karls Universität Tübingen; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; Itä-Suomen Yliopisto; Centre Hospitalier Universitaire de Québec; Manchester Biomedical Research Centre; Monash University; Helsingin Yliopisto; Université Laval; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; National Institutes of Health; Vanderbilt-Ingram Cancer Center; Instituto de Investigación Sanitaria de Santiago de Compostela; Génome Québec; McGill University; Breast Cancer Research Foundation; University of Wisconsin-Milwaukee; National Cancer Institute; University College London; Cancer Research UK; Foundation for the National Institutes of Health; University of Southern California; Stanford Cancer Institute; Cancer Research Institute; Vanderbilt University; Ovarian Cancer Research Fund","keywords":"Surgical oncology; Breast cancer; Medicine; Oncology; Cancer; Bioinformatics; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001133379,0.0002075613,0.0002240447,0.000247851,0.0004794711,0.00006065782,0.0007503579,0.00007289762,0.001904263],"category_scores_gemma":[0.00004879124,0.0002192468,0.00007269584,0.001037485,0.0001614797,0.000009746,0.001014959,0.0006380614,0.00003105349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001215299,"about_ca_system_score_gemma":0.00148818,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01985297,"about_ca_topic_score_gemma":0.01182398,"domain_scores_codex":[0.9967663,0.0005962898,0.0003012745,0.0007957904,0.0007650002,0.0007753308],"domain_scores_gemma":[0.9986953,0.00004207174,0.00008281357,0.0006721645,0.0002872002,0.0002204815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003633138,0.0005223515,0.7940186,0.00008696406,0.0001830657,0.00008794262,0.0007467095,0.01274429,0.05516053,0.00006872145,0.07492003,0.05782763],"study_design_scores_gemma":[0.001102391,0.0001520469,0.9574962,0.00004045874,0.00001829572,0.000181459,0.0004545187,0.0003428229,0.003846157,0.0001292076,0.03587024,0.000366254],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856716,0.001389404,0.00003008971,0.004559696,0.0003542874,0.0006748156,0.006703557,0.00001971335,0.0005967756],"genre_scores_gemma":[0.9951198,0.0002467118,0.00006237645,0.0003450805,0.0006131742,0.002477292,0.0001376139,0.00006757501,0.0009303782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1634775,"threshold_uncertainty_score":0.9990081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220570999245374,"score_gpt":0.3516664786709509,"score_spread":0.3294607686784971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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