{"id":"W4220787401","doi":"10.1186/s13058-021-01484-x","title":"Common variants in breast cancer risk loci predispose to distinct tumor subtypes","year":2022,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of British Columbia; Simon Fraser University; McGill University; Queen's University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Royal Victoria Hospital; Centre hospitalier universitaire de Québec; St. Francis Xavier University; BC Cancer Agency; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Mailman School of Public Health, Columbia University; National Institute of Environmental Health Sciences; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Canadian Institutes of Health Research; University of California, Irvine; University of North Carolina at Chapel Hill; Weill Cornell Medical College; Pontificia Universidad Javeriana; Pomorski Uniwersytet Medyczny W Szczecinie; Universität zu Köln; Deutsche Kinderkrebsstiftung; Medical Research Council; Uppsala Universitet; University of California, San Diego; Carol M. Baldwin Breast Cancer Research Fund; Johns Hopkins University; Universitetet i Oslo; Odense Universitetshospital; Susan G. Komen for the Cure, Komen Wyoming Affiliate; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Johns Hopkins Bloomberg School of Public Health; University of Edinburgh; Queen's University; National Human Genome Research Institute; Cancer Council Victoria; School of Medicine, Vanderbilt University; St. Francis Xavier University; University of Melbourne; School of Medicine, Stanford University; Institut National de la Santé et de la Recherche Médicale; Kuopion Yliopistollinen Sairaala; Universität Heidelberg; Centro de Investigación Biomédica en Red de Cáncer; Universitätsklinikum Köln; Queen's University Belfast; Lunds Universitet; King's College London; Government of Canada; National Health and Medical Research Council; Oulun Yliopisto; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Deutsche Krebshilfe; University of Toronto; Clalit Health Services; Deutsches Krebsforschungszentrum; Biocenter, University of Oulu; National Institute for Health and Care Research; Eberhard Karls Universität Tübingen; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; Itä-Suomen Yliopisto; Centre Hospitalier Universitaire de Québec; Manchester Biomedical Research Centre; Monash University; Helsingin Yliopisto; Université Laval; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; National Institutes of Health; Vanderbilt-Ingram Cancer Center; Instituto de Investigación Sanitaria de Santiago de Compostela; Génome Québec; McGill University; Breast Cancer Research Foundation; University of Wisconsin-Milwaukee; National Cancer Institute; University College London; Cancer Research UK; Foundation for the National Institutes of Health; University of Southern California; Stanford Cancer Institute; Cancer Research Institute; Vanderbilt University; Ovarian Cancer Research Fund","keywords":"Surgical oncology; Breast cancer; Medicine; Oncology; Cancer; Bioinformatics; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002707783,0.0006365943,0.0007092928,0.001450905,0.0005290681,0.0009292454,0.0007099839,0.0009097591,0.003440312],"category_scores_gemma":[0.007478439,0.0003469387,0.001614572,0.002040531,0.0007909219,0.0003195184,0.0008431532,0.0009313573,0.0003341371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004306068,"about_ca_system_score_gemma":0.0005550065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003832791,"about_ca_topic_score_gemma":0.004278706,"domain_scores_codex":[0.997336,0.0006763585,0.0003118353,0.001032408,0.0003817652,0.0002616337],"domain_scores_gemma":[0.9915467,0.004521596,0.002488281,0.000895633,0.000267158,0.0002807176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006088932,0.00004583513,0.9831451,0.00006030386,0.001381234,0.0007238006,0.0002070437,0.001136036,0.005864578,0.0004978444,0.0002103503,0.006118903],"study_design_scores_gemma":[0.00006740116,0.00009557408,0.9899842,0.00003584199,0.0008945308,0.001836448,0.0001360957,0.00301722,0.001090532,0.002163348,0.0006524253,0.00002640099],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933385,0.00102697,0.003698804,0.000169642,0.00001872409,0.00003435479,0.0007649611,0.00007575405,0.0008723526],"genre_scores_gemma":[0.9978884,0.0001549176,0.001224696,0.00005352309,0.00001736993,0.00001625662,0.0005156294,0.00001961154,0.0001095648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003832791,"threshold_uncertainty_score":0.01432025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220570999245374,"score_gpt":0.3516664786709509,"score_spread":0.3294607686784971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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