{"id":"W4220787928","doi":"10.1111/ejn.15647","title":"Inhibition of TRPM7 with carvacrol suppresses glioblastoma functions in vivo","year":2022,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Temozolomide; Cancer research; TRPM7; In vivo; U87; Glioma; Cytotoxicity; Protein kinase B; Chemotherapy; Medicine; Downregulation and upregulation; Biology; In vitro; Internal medicine; Signal transduction; Transient receptor potential channel; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417813,0.0003626732,0.0004932816,0.0002647952,0.000128423,0.0002215327,0.0002750113,0.0003287409,0.0008747902],"category_scores_gemma":[0.0001010249,0.0001113906,0.0003697725,0.0001780615,0.0002062706,0.0002146598,0.0001111219,0.0008541641,0.0002280661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002191441,"about_ca_system_score_gemma":0.0003080595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007516193,"about_ca_topic_score_gemma":0.001057216,"domain_scores_codex":[0.9998822,0.00001656507,0.00001234889,0.00001565553,0.00002322565,0.00004988991],"domain_scores_gemma":[0.9999506,0.000007663022,0.00001196067,0.000005347285,0.000007248537,0.00001714846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001165822,0.0005028864,0.000251245,0.0002018772,0.0000320467,0.00008416241,0.00004215199,0.0002726298,0.9905292,0.0001718407,0.000560168,0.006185961],"study_design_scores_gemma":[0.0001670898,0.004145885,0.003939188,0.0000162737,0.00008480268,0.0002094637,0.0000700471,0.002626635,0.9834874,0.00008836309,0.005154122,0.00001077402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924334,0.003702692,0.001227401,0.0002772047,0.00011866,0.00004454176,0.0004486772,0.000212115,0.001535289],"genre_scores_gemma":[0.9947975,0.002146145,0.0007956644,0.0001282,0.00002389522,0.00006384536,0.0007455048,0.00001747245,0.001281799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008747902,"threshold_uncertainty_score":0.002926469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701141983451165,"score_gpt":0.2476807414546174,"score_spread":0.2306693216201057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}