{"id":"W4220789768","doi":"10.1073/pnas.2117209119","title":"Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Priority Academic Program Development of Jiangsu Higher Education Institutions; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China; Government of Canada","keywords":"microRNA; Neuropathic pain; Histone; Epigenetics; Nociception; Neuroscience; Regulation of gene expression; Chronic pain; DNA methylation; Medicine; Gene expression; Bioinformatics; Gene; Biology; Receptor; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740899,0.0003874464,0.0002920687,0.0001367355,0.0001594503,0.0002443621,0.000188274,0.0002224675,0.001037518],"category_scores_gemma":[0.0001549949,0.0001655874,0.0004331174,0.0001162916,0.0002454661,0.0001691575,0.0001783607,0.0005834122,0.0003190655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379738,"about_ca_system_score_gemma":0.0002567554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000341914,"about_ca_topic_score_gemma":0.0006670096,"domain_scores_codex":[0.9998314,0.00001923937,0.00001648456,0.0000550888,0.0000450097,0.00003269632],"domain_scores_gemma":[0.999929,0.00001059418,0.00002816528,0.000007426741,0.00001107779,0.00001375902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006251041,0.000008241533,0.00008447082,0.00003459294,0.000004603437,0.00001808865,0.000007531617,0.00003169584,0.9987071,0.0000512108,0.00002564089,0.0009643256],"study_design_scores_gemma":[0.00002201646,0.0001966722,0.002763699,0.000005867146,0.00002633179,0.0001503091,0.00001209744,0.00101814,0.9938094,0.00007274262,0.001917702,0.000005058361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761344,0.004246305,0.01555143,0.0002546013,0.0001584978,0.0001025363,0.0005955212,0.0004347882,0.00252193],"genre_scores_gemma":[0.9902996,0.00129262,0.006173817,0.0001339563,0.00002132774,0.00007317109,0.0004159939,0.00006002816,0.00152933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037518,"threshold_uncertainty_score":0.003470838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03009417484238324,"score_gpt":0.3043701882134489,"score_spread":0.2742760133710657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}