{"id":"W4220790507","doi":"10.3389/fneur.2022.809273","title":"Effects of Dimethyl Fumarate on Brain Atrophy in Relapsing-Remitting Multiple Sclerosis: Pooled Analysis Phase 3 DEFINE and CONFIRM Studies","year":2022,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Biogen","keywords":"Dimethyl fumarate; Multiple sclerosis; Placebo; Relapsing remitting; Atrophy; Confidence interval; Medicine; Brain size; Nuclear medicine; Internal medicine; Gastroenterology; Cardiology; Magnetic resonance imaging; Pathology; Radiology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02863691,0.002574051,0.009799452,0.001474891,0.0003838884,0.002155838,0.001122422,0.00154304,0.001990296],"category_scores_gemma":[0.02653407,0.00104324,0.02178971,0.001556899,0.0006158539,0.001282663,0.00144488,0.001133067,0.0003140431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006731161,"about_ca_system_score_gemma":0.001002884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080205,"about_ca_topic_score_gemma":0.002310464,"domain_scores_codex":[0.9778823,0.01652501,0.002030073,0.00166131,0.001484566,0.0004166377],"domain_scores_gemma":[0.983436,0.008182051,0.004601537,0.002007577,0.001429004,0.0003438142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.2957913,0.000333091,0.01350885,0.01310121,0.646751,0.00009124947,0.0001433791,0.001382642,0.003577459,0.0001240794,0.001367505,0.02382818],"study_design_scores_gemma":[0.1034181,0.03451946,0.09903724,0.001490576,0.7505046,0.0002983239,0.0001559616,0.00157863,0.003179308,0.0005883719,0.005056433,0.000172962],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6140803,0.3581079,0.009834099,0.0006173634,0.0009620842,0.003372383,0.009556602,0.0006777026,0.002791653],"genre_scores_gemma":[0.9714607,0.01740546,0.003934858,0.0005804644,0.0004410746,0.002340159,0.002925172,0.0001327056,0.000779307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02863691,"threshold_uncertainty_score":0.1514482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03718590607078791,"score_gpt":0.3113112595412164,"score_spread":0.2741253534704284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}