{"id":"W4220795773","doi":"10.1128/mbio.03656-21","title":"Prokaryotic Argonaute Protein from Natronobacterium gregoryi Requires RNAs To Activate for DNA Interference <i>In Vivo</i>","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"Argonaute; Biology; Plasmid; Bacteriophage; RNA; DNA; Cas9; CRISPR; Cell biology; Genetics; RNA interference; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000111265,0.0001579756,0.0001625602,0.00004858069,0.0001922441,0.00005737945,0.0003748214,0.00003400401,0.006357893],"category_scores_gemma":[0.00002061074,0.0001627684,0.0000749289,0.0001831224,0.00004635557,0.0002721318,0.0005275218,0.0001950597,0.0001983955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388794,"about_ca_system_score_gemma":0.00001673086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001583532,"about_ca_topic_score_gemma":0.001001538,"domain_scores_codex":[0.9988139,0.00005624581,0.000234297,0.0004449936,0.0001050717,0.0003455209],"domain_scores_gemma":[0.9995214,0.00003150558,0.00008269705,0.0002698899,0.00000571101,0.00008877936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001709227,0.0001226657,0.0004264029,0.000005185321,0.000008505861,0.000005606644,0.0004768747,0.00006770405,0.9923497,0.00002426766,0.003488979,0.002853166],"study_design_scores_gemma":[0.0006269491,0.0004889786,0.03175481,0.00005358303,0.00001348628,0.000009569106,0.0002513127,0.0001361883,0.6790624,0.0005288799,0.2866428,0.0004309688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946586,0.000007227628,0.0006127023,0.001490393,0.0004843378,0.001024292,0.0002818186,0.00004385789,0.00139675],"genre_scores_gemma":[0.9905064,0.000001063533,0.001235422,0.0006726275,0.00006029553,0.0007102119,0.00002792669,0.00002441476,0.006761611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3132873,"threshold_uncertainty_score":0.9945504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091042800306601,"score_gpt":0.2263149877303679,"score_spread":0.2154045597273019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}