{"id":"W4220795773","doi":"10.1128/mbio.03656-21","title":"Prokaryotic Argonaute Protein from Natronobacterium gregoryi Requires RNAs To Activate for DNA Interference <i>In Vivo</i>","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"Argonaute; Biology; Plasmid; Bacteriophage; RNA; DNA; Cas9; CRISPR; Cell biology; Genetics; RNA interference; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325778,0.0002415532,0.0001854152,0.0000821154,0.000240007,0.0001492815,0.0002101869,0.0003357735,0.0006399006],"category_scores_gemma":[0.0001762502,0.0001106234,0.000250244,0.0000617176,0.0002676662,0.0001880097,0.0003047896,0.0004895686,0.0003836652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003087782,"about_ca_system_score_gemma":0.0001892617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007817008,"about_ca_topic_score_gemma":0.002108657,"domain_scores_codex":[0.9999099,0.00001146769,0.000007403518,0.00002394621,0.0000261791,0.0000211074],"domain_scores_gemma":[0.9998885,0.000038648,0.00002527424,0.00001860385,0.000009579435,0.00001934547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001481369,0.00000346324,0.0001362877,0.00001380803,9.949173e-7,0.00004003214,0.00001279503,0.00002049067,0.9993337,0.0001113346,0.00001591439,0.0002964321],"study_design_scores_gemma":[0.000002137027,0.00005131208,0.002510597,0.000002111417,0.000003983828,0.0001903797,0.00001923761,0.0005887132,0.9950117,0.00006820422,0.001547167,0.000004425274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910885,0.0008413821,0.005514229,0.000154716,0.0000363551,0.00001750289,0.0001679657,0.000122239,0.002057016],"genre_scores_gemma":[0.9922823,0.0002682465,0.004657586,0.00009048973,0.000006605056,0.00001704928,0.0004443573,0.00005113153,0.002182195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007817008,"threshold_uncertainty_score":0.00224036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091042800306601,"score_gpt":0.2263149877303679,"score_spread":0.2154045597273019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}