{"id":"W4220796889","doi":"10.1101/2022.03.21.22272043","title":"DNAmFitAge: Biological Age Indicator Incorporating Physical Fitness","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council","keywords":"dNaM; Epigenetics; Physical fitness; Grip strength; Biological age; Gerontology; DNA methylation; Medicine; Bioinformatics; Biology; Physical therapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004834284,0.0003178524,0.0003395187,0.00007263671,0.0001602466,0.00005287593,0.0005612801,0.0003919033,0.00009957856],"category_scores_gemma":[0.0002019982,0.0002951655,0.00023253,0.00007687457,0.0001442316,0.000001458489,0.001895148,0.0006223966,0.00001583488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003037445,"about_ca_system_score_gemma":0.0001301753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001350759,"about_ca_topic_score_gemma":0.00000718411,"domain_scores_codex":[0.9980163,0.0002872024,0.0003261094,0.0008222236,0.0002701245,0.0002780553],"domain_scores_gemma":[0.998773,0.00003354875,0.0003116838,0.0007161555,0.00004400667,0.0001215404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004999351,0.0002805037,0.2389791,0.00009030675,0.0001157506,0.00006801094,0.0002007522,0.001392908,0.7543051,0.0003077175,0.0001632589,0.004046592],"study_design_scores_gemma":[0.001268921,0.001386772,0.3552148,0.00006674853,0.0001466377,0.000007724702,0.0002091811,0.00100186,0.536931,0.01823737,0.08300649,0.002522441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951465,0.001268759,0.00107956,0.00009360608,0.0005679957,0.0003121149,0.00009735728,0.00003840672,0.001395697],"genre_scores_gemma":[0.9955876,0.000216242,0.0009714061,0.00007089329,0.0009017144,0.0001736666,0.001725207,0.00004727155,0.0003059807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2173741,"threshold_uncertainty_score":0.9999501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143950461776589,"score_gpt":0.3007415450724906,"score_spread":0.2693020404547247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}