{"id":"W4220796889","doi":"10.1101/2022.03.21.22272043","title":"DNAmFitAge: Biological Age Indicator Incorporating Physical Fitness","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council","keywords":"dNaM; Epigenetics; Physical fitness; Grip strength; Biological age; Gerontology; DNA methylation; Medicine; Bioinformatics; Biology; Physical therapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001127651,0.0006329142,0.0006033801,0.001485009,0.0001981277,0.0006517082,0.0004826371,0.000655797,0.002703673],"category_scores_gemma":[0.004639727,0.0002203169,0.000507135,0.0009769757,0.000189874,0.0004764219,0.0007747392,0.000573239,0.0008990561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000287056,"about_ca_system_score_gemma":0.0003916792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001671902,"about_ca_topic_score_gemma":0.002190293,"domain_scores_codex":[0.9995696,0.0001010978,0.00002546364,0.0001979451,0.00007141148,0.00003443079],"domain_scores_gemma":[0.9991405,0.0003363236,0.0002107605,0.0001523225,0.00009801721,0.0000620404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001275701,0.0003053438,0.6098403,0.0007738696,0.001070946,0.0001668496,0.0003271911,0.02357918,0.02414446,0.006563725,0.03141455,0.3005379],"study_design_scores_gemma":[0.0002126419,0.0007642548,0.7247214,0.0001871018,0.0004716875,0.0007829091,0.0001359816,0.1351544,0.03374064,0.01973506,0.08383502,0.0002588899],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5605167,0.003709647,0.3124646,0.0007860248,0.0005341918,0.0002786606,0.100665,0.01487335,0.006171713],"genre_scores_gemma":[0.7206213,0.0008408769,0.2036803,0.0004310232,0.0002648423,0.0007288358,0.06558821,0.0006771633,0.007167467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002703673,"threshold_uncertainty_score":0.009044647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143950461776589,"score_gpt":0.3007415450724906,"score_spread":0.2693020404547247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}