{"id":"W4220799525","doi":"10.1158/1538-7445.sabcs21-gs1-02","title":"Abstract GS1-02: Final results of KEYNOTE-355: Randomized, double-blind, phase 3 study of pembrolizumab + chemotherapy vs placebo + chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Gemcitabine; Carboplatin; Pembrolizumab; Internal medicine; Taxane; Hazard ratio; Population; Oncology; Placebo; Chemotherapy; Breast cancer; Clinical endpoint; Cancer; Confidence interval; Clinical trial; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003441386,0.002536625,0.003211758,0.0005666091,0.0005956298,0.001434627,0.001473607,0.002487504,0.01655416],"category_scores_gemma":[0.002276619,0.0008956357,0.002711547,0.0005704299,0.001583817,0.001284613,0.0006378192,0.003843964,0.002187974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001225508,"about_ca_system_score_gemma":0.002284367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009499518,"about_ca_topic_score_gemma":0.002888986,"domain_scores_codex":[0.9988301,0.0006680394,0.00007574027,0.0001908837,0.00008481407,0.0001504153],"domain_scores_gemma":[0.9988887,0.0002238726,0.0002532463,0.0001325042,0.00008508502,0.0004165099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.981767,0.004331614,0.0003727684,0.0004670994,0.0009251136,0.00002905135,0.000024557,0.0002447598,0.003596957,0.0001070439,0.001648908,0.006485012],"study_design_scores_gemma":[0.9547806,0.04237948,0.001231951,0.00002220256,0.0004546679,0.00001995561,0.000009356738,0.0001173197,0.0003235459,0.0001254028,0.0005243999,0.00001101278],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502434,0.005812838,0.001733442,0.002139901,0.001118695,0.01993594,0.01197458,0.0006248257,0.006416372],"genre_scores_gemma":[0.9634937,0.002055741,0.003358469,0.00414105,0.0007455685,0.01186283,0.007904977,0.00008660272,0.006351009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01655416,"threshold_uncertainty_score":0.05537915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1262927204348393,"score_gpt":0.4541896713619176,"score_spread":0.3278969509270783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}