{"id":"W4220802415","doi":"10.22541/au.164873474.40297753/v1","title":"EVIDENCE FOR HETERODIMERIZATION AND FUNCTIONAL INTERACTION OF THE UROTENSIN II AND THE ANGIOTENSIN II TYPE 1 RECEPTORS","year":2022,"lang":"en","type":"preprint","venue":"","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Armand Frappier Museum","funders":"","keywords":"Allosteric regulation; Receptor; G protein-coupled receptor; Signal transduction; HEK 293 cells; Cell biology; Angiotensin II; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006461036,0.0001538216,0.0003504636,0.00009174628,0.0003932017,0.00002814477,0.00008202259,0.00007685647,0.0002650709],"category_scores_gemma":[0.001276186,0.00008528906,0.0002629133,0.0001659896,0.0003678984,0.00005938117,0.001231152,0.0004981338,5.604435e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004908167,"about_ca_system_score_gemma":0.0001213836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002182892,"about_ca_topic_score_gemma":0.00002049142,"domain_scores_codex":[0.9984568,0.0003402522,0.000244879,0.0003873125,0.0004485065,0.0001222421],"domain_scores_gemma":[0.9984944,0.0004183944,0.0001378293,0.0004530599,0.0004532657,0.00004301457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.09133796,0.001091015,0.04124742,0.00581524,0.01258561,0.00003452687,0.01588024,0.01061247,0.2773055,0.004527065,0.2451787,0.2943842],"study_design_scores_gemma":[0.01675976,0.004226186,0.5827792,0.004604153,0.004147313,0.0007661956,0.003078511,0.02008004,0.05500023,0.001476769,0.3057587,0.001322827],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775851,0.005990519,0.001674897,0.00825764,0.002229919,0.003284849,0.00003193015,0.00003686998,0.0009082523],"genre_scores_gemma":[0.9899746,0.00366923,0.0003211911,0.0003954874,0.0002823341,0.00007461789,0.00007930669,0.0000290087,0.005174203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5415319,"threshold_uncertainty_score":0.3477987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1160754479595344,"score_gpt":0.3437035663177536,"score_spread":0.2276281183582192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}