{"id":"W4220802415","doi":"10.22541/au.164873474.40297753/v1","title":"EVIDENCE FOR HETERODIMERIZATION AND FUNCTIONAL INTERACTION OF THE UROTENSIN II AND THE ANGIOTENSIN II TYPE 1 RECEPTORS","year":2022,"lang":"en","type":"preprint","venue":"","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Armand Frappier Museum","funders":"","keywords":"Allosteric regulation; Receptor; G protein-coupled receptor; Signal transduction; HEK 293 cells; Cell biology; Angiotensin II; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002547493,0.0002318849,0.0001432704,0.0001467687,0.0001892659,0.0003698755,0.0002094705,0.0003623466,0.002786021],"category_scores_gemma":[0.0003218901,0.0001508637,0.0002455312,0.0001119862,0.000211347,0.0002414401,0.0003373146,0.0005201579,0.0006508112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698475,"about_ca_system_score_gemma":0.00007125139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002123014,"about_ca_topic_score_gemma":0.000209384,"domain_scores_codex":[0.9997012,0.00005898275,0.00002629553,0.0000945053,0.0000586649,0.00006029834],"domain_scores_gemma":[0.9997112,0.0000749046,0.0000764935,0.00004649181,0.00003455175,0.00005627623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007618908,0.00002557394,0.0009794171,0.00003991712,0.00001033489,0.0001039385,0.00002177577,0.00001820751,0.9976508,0.0002065174,0.00009429464,0.0007729657],"study_design_scores_gemma":[0.00005903806,0.000688101,0.09680153,0.00003508521,0.00008552778,0.005715807,0.0004419148,0.003597305,0.8802682,0.0006104638,0.01166989,0.00002718338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907169,0.002437011,0.004065548,0.0002769388,0.00006883107,0.00001849829,0.0002501941,0.00004074522,0.002125347],"genre_scores_gemma":[0.9961261,0.0006997838,0.001281919,0.0001464181,0.00003216176,0.0000233701,0.0004831477,0.0000097165,0.001197324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002786021,"threshold_uncertainty_score":0.00932014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1160754479595344,"score_gpt":0.3437035663177536,"score_spread":0.2276281183582192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}