{"id":"W4220803013","doi":"10.21203/rs.3.rs-1427931/v1","title":"Combination Treatment with Histone Deacetylase and Carbonic Anhydrase 9 Inhibitors Shows Therapeutic Potential in Experimental Diffuse Intrinsic Pontine Glioma","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Curing Kids Cancer; Cure Starts Now Foundation","keywords":"Panobinostat; Vorinostat; Histone deacetylase; Cancer research; Combination therapy; Glioma; Cell cycle; Histone deacetylase inhibitor; Cell growth; Histone; Carbonic anhydrase; Chemistry; Population; Biology; Apoptosis; Pharmacology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001504438,0.0003977876,0.0005373624,0.0003046534,0.0001288028,0.0002078595,0.0002719702,0.000194623,0.001143244],"category_scores_gemma":[0.00008179271,0.0001002356,0.0003317372,0.0002316051,0.0002374532,0.000179593,0.0001663002,0.0005216738,0.0001461703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752841,"about_ca_system_score_gemma":0.0002811337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007909664,"about_ca_topic_score_gemma":0.002069716,"domain_scores_codex":[0.9998881,0.00001756397,0.000006990091,0.00002302474,0.0000336088,0.00003072641],"domain_scores_gemma":[0.9999542,0.000006281417,0.00001105297,0.000006453132,0.000004871929,0.00001709373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003712532,0.0009217477,0.001405417,0.000336326,0.00009881113,0.0004129316,0.000035212,0.0003176103,0.9719827,0.00008724003,0.0002662756,0.02042321],"study_design_scores_gemma":[0.0007977418,0.03280748,0.01767962,0.00002156246,0.000310013,0.001873505,0.00008853097,0.001714091,0.9393693,0.00007027114,0.005251135,0.00001678884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952306,0.002880951,0.0007405103,0.00007991458,0.00002988765,0.00007024393,0.0001503648,0.00005767471,0.0007598342],"genre_scores_gemma":[0.9964656,0.001543079,0.0009614129,0.00003732535,0.00001474892,0.00005171005,0.0002993317,0.000007693448,0.0006192581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143244,"threshold_uncertainty_score":0.003824532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220221926128552,"score_gpt":0.3499680703341604,"score_spread":0.3277658510728749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}