{"id":"W4220803013","doi":"10.21203/rs.3.rs-1427931/v1","title":"Combination Treatment with Histone Deacetylase and Carbonic Anhydrase 9 Inhibitors Shows Therapeutic Potential in Experimental Diffuse Intrinsic Pontine Glioma","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Curing Kids Cancer; Cure Starts Now Foundation","keywords":"Panobinostat; Vorinostat; Histone deacetylase; Cancer research; Combination therapy; Glioma; Cell cycle; Histone deacetylase inhibitor; Cell growth; Histone; Carbonic anhydrase; Chemistry; Population; Biology; Apoptosis; Pharmacology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009698434,0.0005653704,0.000535227,0.001000687,0.0003867607,0.0001583445,0.0004425051,0.0004551642,0.0001250629],"category_scores_gemma":[0.00007954691,0.0005314216,0.0001771395,0.000529137,0.0005840121,0.00001399616,0.00175066,0.001339046,0.000007805887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001839672,"about_ca_system_score_gemma":0.0009703901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002330019,"about_ca_topic_score_gemma":0.001436463,"domain_scores_codex":[0.9943448,0.001262772,0.0004929167,0.001473713,0.001427345,0.0009985096],"domain_scores_gemma":[0.9980758,0.00006655615,0.0001436057,0.001089156,0.0002674705,0.0003574475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002960202,0.004706969,0.002293193,0.0003363407,0.0002562312,0.001500097,0.001234,0.0002947734,0.980302,0.00005339154,0.000648553,0.005414251],"study_design_scores_gemma":[0.01148885,0.01258368,0.002552279,0.0002782142,0.00005286566,0.000159307,0.002342102,0.0008244258,0.9634938,0.00006112768,0.005019084,0.001144274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832708,0.01341132,0.00001207821,0.000349812,0.0001941713,0.002348588,0.0001234337,0.00003731217,0.0002525143],"genre_scores_gemma":[0.9949326,0.0009053775,0.00005640016,0.00001734422,0.0002865941,0.00154689,0.00111902,0.0001380763,0.0009976922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01680821,"threshold_uncertainty_score":0.9997137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220221926128552,"score_gpt":0.3499680703341604,"score_spread":0.3277658510728749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}