{"id":"W4220805592","doi":"10.1016/j.tibs.2022.03.005","title":"System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory","year":2022,"lang":"en","type":"letter","venue":"Trends in Biochemical Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Topoisomerase; Reset (finance); Transcription (linguistics); DNA polymerase; Cell biology; DNA; Biology; Mitosis; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002617596,0.001058832,0.0009147885,0.0005559024,0.002004701,0.003597419,0.001379966,0.02336848,0.007912309],"category_scores_gemma":[0.009602067,0.0006300632,0.0008435601,0.0002963216,0.003183832,0.002516465,0.001522725,0.02225049,0.005379792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00370208,"about_ca_system_score_gemma":0.001514458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065213,"about_ca_topic_score_gemma":0.001609941,"domain_scores_codex":[0.9988531,0.0002208811,0.0001071494,0.0002205956,0.0003822063,0.0002160322],"domain_scores_gemma":[0.9971015,0.001711921,0.0002793742,0.0002174526,0.0002791758,0.0004106359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007142412,0.00005844984,0.0008467262,0.0002084518,0.00007279274,0.004410665,0.0001152217,0.0002923348,0.005620622,0.01969557,0.9354212,0.03254391],"study_design_scores_gemma":[0.001168855,0.0005242827,0.001563632,0.0001966251,0.0001096191,0.005653154,0.0002291808,0.00317781,0.01367525,0.07278558,0.9008053,0.0001107768],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.002536746,0.008440956,0.001541606,0.9070095,0.07191897,0.00004424738,0.0001349324,0.0003062075,0.008066746],"genre_scores_gemma":[0.04374229,0.006197188,0.001237422,0.8058083,0.1159965,0.000159728,0.0001288184,0.00008053863,0.02664919],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02336848,"threshold_uncertainty_score":0.02686054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03764053515670585,"score_gpt":0.298719261315309,"score_spread":0.2610787261586032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}