{"id":"W4220805592","doi":"10.1016/j.tibs.2022.03.005","title":"System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory","year":2022,"lang":"en","type":"letter","venue":"Trends in Biochemical Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Topoisomerase; Reset (finance); Transcription (linguistics); DNA polymerase; Cell biology; DNA; Biology; Mitosis; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003983273,0.0002774324,0.0002844803,0.0002211265,0.0001906466,0.00005205806,0.0007177519,0.000481422,0.0002808934],"category_scores_gemma":[0.0000155563,0.0002590981,0.0002690007,0.000366496,0.0002949088,0.00000388722,0.0001100299,0.0004457984,0.000002628671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234649,"about_ca_system_score_gemma":0.0001302235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000044738,"about_ca_topic_score_gemma":0.00001856683,"domain_scores_codex":[0.9977219,0.00007432643,0.0003293019,0.000867195,0.0004638776,0.0005434383],"domain_scores_gemma":[0.9994423,0.00003602781,0.0001113329,0.0003117382,0.00003235143,0.00006622255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001339428,0.00004986311,0.000005153126,0.00011578,0.00004515936,0.00001838236,0.0000368998,0.00001923881,0.4664669,0.0003299105,0.5295391,0.003239683],"study_design_scores_gemma":[0.0005960157,0.0005598668,0.00001073037,0.00003987202,0.00003738619,0.00002703823,0.000122303,0.00009395568,0.09223991,0.0002063715,0.9056345,0.000432113],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3260262,0.02086233,0.0009832899,0.6140074,0.01134257,0.002444541,0.005129467,0.0002391966,0.01896504],"genre_scores_gemma":[0.5963832,0.00047655,0.003198245,0.3573503,0.01228597,0.001696143,0.008877465,0.0002365376,0.01949555],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3760953,"threshold_uncertainty_score":0.9999861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03764053515670585,"score_gpt":0.298719261315309,"score_spread":0.2610787261586032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}