{"id":"W4220805673","doi":"10.3389/fonc.2022.818679","title":"Phase 1 Clinical Trial Evaluating the Safety and Anti-Tumor Activity of ADP-A2M10 SPEAR T-Cells in Patients With MAGE-A10+ Head and Neck, Melanoma, or Urothelial Tumors","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Moonshot Research and Development Program; National Institutes of Health","keywords":"Medicine; Fludarabine; Neutropenia; Internal medicine; Melanoma; Leukopenia; Gastroenterology; Context (archaeology); Oncology; Cyclophosphamide; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003522548,0.0001784671,0.0009609734,0.0002374639,0.0001147452,0.000009357831,0.0001768588,0.00009960629,0.0005558428],"category_scores_gemma":[0.0005353963,0.0001226938,0.00006587945,0.000370643,0.0005555445,0.00005683506,0.0002438139,0.000996026,8.206758e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003567405,"about_ca_system_score_gemma":0.0008354143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001917664,"about_ca_topic_score_gemma":0.0001341719,"domain_scores_codex":[0.9961715,0.001776023,0.0006721324,0.0004662433,0.0005219379,0.0003921245],"domain_scores_gemma":[0.9984706,0.0007429088,0.000272785,0.0003298204,0.00005922497,0.0001246366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5366594,0.003552126,0.3001547,0.0000415296,0.00009187352,0.0001950731,0.0007451678,0.00002177007,0.001492088,0.000002730866,0.0005946541,0.1564488],"study_design_scores_gemma":[0.5666161,0.1400047,0.2696351,0.00009076189,0.000149955,0.00006948556,0.001475947,0.005693609,0.0004607162,0.00004737237,0.01543287,0.0003234684],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955093,0.0001025587,0.00005951589,0.0004255281,0.0007456999,0.002644764,0.00006373251,0.000009504409,0.000439399],"genre_scores_gemma":[0.9964778,0.00008751218,0.00225163,0.0002473682,0.0001710264,0.00008911144,0.00001423375,0.00003552271,0.0006257374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1561254,"threshold_uncertainty_score":0.6086089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06616726927313714,"score_gpt":0.4223646722286237,"score_spread":0.3561974029554866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}