{"id":"W4220805673","doi":"10.3389/fonc.2022.818679","title":"Phase 1 Clinical Trial Evaluating the Safety and Anti-Tumor Activity of ADP-A2M10 SPEAR T-Cells in Patients With MAGE-A10+ Head and Neck, Melanoma, or Urothelial Tumors","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Moonshot Research and Development Program; National Institutes of Health","keywords":"Medicine; Fludarabine; Neutropenia; Internal medicine; Melanoma; Leukopenia; Gastroenterology; Context (archaeology); Oncology; Cyclophosphamide; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009480945,0.001237045,0.001321593,0.0002247166,0.0003916113,0.0009423842,0.0005894694,0.001300336,0.006057068],"category_scores_gemma":[0.0006763996,0.0004146923,0.0007450773,0.0002620559,0.0006077972,0.0006851318,0.0002475581,0.002935802,0.001094151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007332426,"about_ca_system_score_gemma":0.001342902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004224048,"about_ca_topic_score_gemma":0.001426884,"domain_scores_codex":[0.9997378,0.00009990999,0.00001098867,0.00006552508,0.00002241417,0.00006337996],"domain_scores_gemma":[0.9995862,0.00006379937,0.000076697,0.00003133358,0.00003173944,0.0002103297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6798859,0.1082119,0.006858206,0.001149723,0.0009971269,0.0006533421,0.0003586963,0.004304925,0.08779568,0.001071089,0.01441387,0.09429953],"study_design_scores_gemma":[0.4459303,0.5311213,0.005972196,0.00005113054,0.0003084214,0.0005709279,0.00007442587,0.001514646,0.007011592,0.0006217826,0.006794601,0.00002868322],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866304,0.001660268,0.0008936318,0.0005941409,0.0002399434,0.004575107,0.002085276,0.0001261313,0.003195071],"genre_scores_gemma":[0.979859,0.001341228,0.002079492,0.001268955,0.0001871066,0.005630466,0.003576228,0.00003547125,0.006022012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006057068,"threshold_uncertainty_score":0.02026284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06616726927313714,"score_gpt":0.4223646722286237,"score_spread":0.3561974029554866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}